Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H27NO2 |
Molecular Weight | 325.4446 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)CCOC1=CC=CC=C1C(=O)CCC2=CC=CC=C2
InChI
InChIKey=OEGDFSLNGABBKJ-UHFFFAOYSA-N
InChI=1S/C21H27NO2/c1-3-22(4-2)16-17-24-21-13-9-8-12-19(21)20(23)15-14-18-10-6-5-7-11-18/h5-13H,3-4,14-17H2,1-2H3
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6482088 | https://www.ncbi.nlm.nih.gov/pubmed/582134 | https://www.ncbi.nlm.nih.gov/pubmed/469443 | https://www.ncbi.nlm.nih.gov/pubmed/94412 | http://www.drugfuture.com/chemdata/etafenone.html | https://www.ncbi.nlm.nih.gov/pubmed/582134 | https://www.ncbi.nlm.nih.gov/pubmed/94412 | https://www.ncbi.nlm.nih.gov/pubmed/1037264 | https://www.ncbi.nlm.nih.gov/pubmed/1786372
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6482088 | https://www.ncbi.nlm.nih.gov/pubmed/582134 | https://www.ncbi.nlm.nih.gov/pubmed/469443 | https://www.ncbi.nlm.nih.gov/pubmed/94412 | http://www.drugfuture.com/chemdata/etafenone.html | https://www.ncbi.nlm.nih.gov/pubmed/582134 | https://www.ncbi.nlm.nih.gov/pubmed/94412 | https://www.ncbi.nlm.nih.gov/pubmed/1037264 | https://www.ncbi.nlm.nih.gov/pubmed/1786372
Etafenone is an antiarrhythmic and coronary vasodilator drug. Etafenone exerts negative inotropic action on myocardium. It is able to block calcium channels. As a coronary vasodilator which produces a decrease in the heart rate and myocardial oxygen consumption, etafenone has been used in the therapy of ischemic heart disease.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10888308
Curator's Comment: Etafenone induces catalepsy in mice. No human data available.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL3071 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10888308 |
2.43 µM [Ki] | ||
Target ID: CHEMBL3427 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10888308 |
3.92 µM [Ki] | ||
Target ID: CHEMBL2097162 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10888308 |
0.184 µM [Ki] | ||
Target ID: GO:0014829 |
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Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | DIALICOR Approved UseUnknown |
PubMed
Title | Date | PubMed |
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[Clinical study of a new synthetic drug with coronary-dilatatory action (LG-11457)]. | 1960 Sep 1 |
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[Pharmacological study of some properties of LG-11457. Action on ventricular extrasystoles, on spasm of smooth muscles and on the peripheral circulation]. | 1960 Sep 1 |
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Effects of etafenone on myocardial energy metabolism as studied by an organ redoximeter and biochemical analyses. | 1984 Jul |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6482088
After etafenone 1 uM, there was a significant prolongation of the time to the detectable or the maximum increase in NADH fluorescence in isolated perfused guinea pig heart
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C48149
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WHO-VATC |
QC01DX07
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WHO-ATC |
C01DX07
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3275
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90-54-0
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1069
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100000082367
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2451
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Etafenone
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m5035
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202-002-9
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0I14K589E7
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SUB07257MIG
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C65548
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C001162
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DTXSID6046181
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DB13845
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CHEMBL1736151
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)