ETAFENONE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H27NO2
Molecular Weight	325.4446
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCN(CC)CCOC1=CC=CC=C1C(=O)CCC2=CC=CC=C2

InChI

InChIKey=OEGDFSLNGABBKJ-UHFFFAOYSA-N

InChI=1S/C21H27NO2/c1-3-22(4-2)16-17-24-21-13-9-8-12-19(21)20(23)15-14-18-10-6-5-7-11-18/h5-13H,3-4,14-17H2,1-2H3

HIDE SMILES / InChI

Description

Etafenone is an antiarrhythmic and coronary vasodilator drug. Etafenone exerts negative inotropic action on myocardium. It is able to block calcium channels. As a coronary vasodilator which produces a decrease in the heart rate and myocardial oxygen consumption, etafenone has been used in the therapy of ischemic heart disease.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Dopamine D1 receptor 101	Binding Agent 1,064	2.43 µM [Ki]
Dopamine D2 receptor 297	Binding Agent 1,064	3.92 µM [Ki]
Muscarinic acetylcholine receptor 160	Binding Agent 1,064	0.184 µM [Ki]
vascular smooth muscle contraction 5	Inhibitor 8,297
Voltage-gated calcium channel 37	Blocker 537

Conditions

Condition	Modality	Targets	Highest Phase	Product
Angina pectoris 106	Primary		Approved 8,429	DIALICOR

PubMed

Show entries

Title	Date	PubMed
[Clinical study of a new synthetic drug with coronary-dilatatory action (LG-11457)].	1960 Sep 1	13722451
[Pharmacological study of some properties of LG-11457. Action on ventricular extrasystoles, on spasm of smooth muscles and on the peripheral circulation].	1960 Sep 1	13721592
[Preliminary observations on the treatment of coronary insufficiency with 2'-(2-diethylaminoethoxy)-3-phenylpropiophenone hydrochloride (LG--11457)].	1960 Sep 1	13692742
[Pharmacological and toxicological studies on the effect characterization of etafenone].	1969 Oct	5395365
Effects of etafenone and antiarrhythmic drugs on Na and Ca channels of guinea pig atrial muscle.	1979 Sep-Oct	94412

Showing 1 to 5 of 7 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Parenteral

In Vitro Use Guide

After etafenone 1 uM, there was a significant prolongation of the time to the detectable or the maximum increase in NADH fluorescence in isolated perfused guinea pig heart

Show entries

Name

Type

Language

ETAFENONE

Official Name

English

ETAFENONE [MI]

Common Name

English

etafenone [INN]

Common Name

English

Etafenone [WHO-DD]

Common Name

English

2'-(2-(DIETHYLAMINO)ETHOXY)-3-PHENYLPROPIOPHENONE

Systematic Name

English

Showing 1 to 5 of 5 entries

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Show entries

Classification Tree

Code System

Code

Adrenergic Agonist

NCI_THESAURUS

C48149

Other vasodilators used in cardiac diseases

WHO-VATC

QC01DX07

Other vasodilators used in cardiac diseases

WHO-ATC

C01DX07

Showing 1 to 3 of 3 entries

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Show entries

Code System

Code

Type

Description

PUBCHEM

3275

PRIMARY

CAS

90-54-0

PRIMARY

DRUG CENTRAL

1069

PRIMARY

SMS_ID

100000082367

PRIMARY

INN

2451

PRIMARY

Showing 1 to 5 of 15 entries

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ACTIVE MOIETY


					0I14K589E7

ETAFENONE

SALT/SOLVATE (PARENT)


					NTS160XKGC

ETAFENONE HYDROCHLORIDE