XIBENOLOL

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H25NO2
Molecular Weight	251.3645
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C)C(OCC(O)CNC(C)(C)C)=CC=C1

InChI

InChIKey=RKUQLAPSGZJLGP-UHFFFAOYSA-N

InChI=1S/C15H25NO2/c1-11-7-6-8-14(12(11)2)18-10-13(17)9-16-15(3,4)5/h6-8,13,16-17H,9-10H2,1-5H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8021 | https://www.ncbi.nlm.nih.gov/pubmed/6131020 | http://adisinsight.springer.com/drugs/800000135

Xibenolol or D-32 (dl-tert-butylamino-3-(2', 3'-dimethylphenoxy)-2-propanol hydrochloride) is a beta-blocking agent. It has been developing as a hypontesive medicine by Kowa Pharmaceutical and Teikoku Hormone, however development has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 87 Target ID: CHEMBL2094118 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8021 \| https://www.ncbi.nlm.nih.gov/pubmed/6131020 \| http://adisinsight.springer.com/drugs/800000135	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6131020 https://www.ncbi.nlm.nih.gov/pubmed/15525 https://www.ncbi.nlm.nih.gov/pubmed/8021	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Analysis of beta-adrenoceptors mediating renin release produced by isoproterenol in conscious dogs.	1980 May	6103674

Patents

Sample Use Guides

In Vivo Use Guide

dogs: 50 mg/kg, p.o. 1 mg/kg per min for 5 min i.v. rats: 2 X 15 or 2 X 50 mg/kg/day p.o.

Route of Administration: Other

In Vitro Use Guide

The effects of xibenolol (D-32) (17.3-100 uM) on action potentials were investigated in isolated guinea-pig papillary muscles.

Name

Type

Language

XIBENOLOL

Official Name

English

(±)-1-(TERT-BUTYLAMINO)-3-(2,3-XYLYLOXY)-2-PROPANOL

Systematic Name

English

XIBENOLOL [MI]

Common Name

English

xibenolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576