MERCAPTOMERIN SODIUM

US Previously Marketed

First approved in 1949

Details

Stereochemistry	MIXED
Molecular Formula	C16H25HgNO6S.2Na
Molecular Weight	606.01
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].COC(CNC(=O)C1CCC(C)(C([O-])=O)C1(C)C)C[Hg]SCC([O-])=O

InChI

InChIKey=RQXWFEXQGWCOGQ-UHFFFAOYSA-K

InChI=1S/C14H24NO4.C2H4O2S.Hg.2Na/c1-9(19-5)8-15-11(16)10-6-7-14(4,12(17)18)13(10,2)3;3-2(4)1-5;;;/h9-10H,1,6-8H2,2-5H3,(H,15,16)(H,17,18);5H,1H2,(H,3,4);;;/q;;3*+1/p-3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18137278 | https://www.ncbi.nlm.nih.gov/pubmed/18123664 | https://www.ncbi.nlm.nih.gov/pubmed/13182225

MERCAPTOMERIN is a mercurial diuretic used for the treatment of congestive heart failure. It is an effective diuretic not only when given intramuscularly and intravenously but also when given subcutaneously.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Congestive Heart Failure 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18137278 http://circ.ahajournals.org/content/1/4/502	Palliative		Not Provided 504	Thiomerin Approved Use Unknown

PubMed

Title	Date	PubMed
The subcutaneous administration of mercaptomerin; effective mercurial diuretic for the treatment of congestive heart failure.	1949 Aug 20	18137278
Treatment of myocardial failure; studies of a new and safe diuretic, thiomerin.	1949 Feb	18123664
Clinical studies on thiomerin, a new mercurial diuretic.	1949 Sep	18139576
A trial of mercaptomerin in severe congestive heart failure.	1954 Aug 14	13182225

Name

Type

Language

MERCAPTOMERIN SODIUM

Common Name

English

LETORIN

Brand Name

English

DISODIUM N-(3-(CARBOXYMETHYLTHIOMERCURI)-2-METHOXYPROPYL)-.ALPHA.-CAMPHORAMATE

Common Name

English

SODIUM MERCAPTOMERIN

Common Name

English

N-(.GAMMA.-CARBOXYMETHYLMERCAPTOMERCURI-.BETA.-METHOXY)PROPYLCAMPHORAMIC ACID DISODIUM SALT

Common Name

English

Mercaptomerin sodium [WHO-DD]

Common Name

English

DIUCARDYN SODIUM

Brand Name

English

MERCAPTOMERIN SODIUM [MI]

Common Name

English

MERCURATE(2-), (3-(((3-CARBOXYLATO-2,2,3-TRIMETHYLCYCLOPENTYL)CARBONYL-.KAPPA.O)AMINO)-2-METHOXYPROPYL-.KAPPA.C)(2-(MERCAPTO-.KAPPA.S)ACETATO(2-)-.KAPPA.O)-, SODIUM (1:2), (T-4)-

Common Name

English

MERCURY, (3-(((3-CARBOXY-2,2,3-TRIMETHYLCYCLOPENTYL)CARBONYL)AMINO)-2-METHOXYPROPYL)(MERCAPTOACETATO-S)-, DISODIUM SALT

Common Name

English

CYCLOPENTANECARBOXYLIC ACID, 3-(((2-METHOXYPROPYL)AMINO)CARBONYL)-1,2,2-TRIMETHYL-, MERCURY COMPLEX

Common Name

English

THIOMERIN SODIUM

Brand Name

English

[3-(3-Carboxy-2,2,3-trimethylcyclopentanecarboxamido)-2-methoxypropyl](hydrogen mercaptoacetato)mercury disodium salt

Common Name

English

(T-4)-(3-(((3-CARBOXYLATO-2,2,3-TRIMETHYLCYCLOPENTYL)CARBONYL)AMINO)-2-METHOXYPROPYL)(MERCAPTOACETATO(2-)-O,S)MERCURATE(2-) DISODIUM

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID801016486