MERCAPTOMERIN SODIUM

US Previously Marketed

First approved in 1949

Details

Stereochemistry	MIXED
Molecular Formula	C16H25HgNO6S.2Na
Molecular Weight	606.01
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].COC(CNC(=O)C1CCC(C)(C([O-])=O)C1(C)C)C[Hg]SCC([O-])=O

InChI

InChIKey=RQXWFEXQGWCOGQ-UHFFFAOYSA-K

InChI=1S/C14H24NO4.C2H4O2S.Hg.2Na/c1-9(19-5)8-15-11(16)10-6-7-14(4,12(17)18)13(10,2)3;3-2(4)1-5;;;/h9-10H,1,6-8H2,2-5H3,(H,15,16)(H,17,18);5H,1H2,(H,3,4);;;/q;;3*+1/p-3

HIDE SMILES / InChI

Molecular Formula	C16H25HgNO6S
Molecular Weight	560.03
Charge	-2
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18137278 | https://www.ncbi.nlm.nih.gov/pubmed/18123664 | https://www.ncbi.nlm.nih.gov/pubmed/13182225

MERCAPTOMERIN is a mercurial diuretic used for the treatment of congestive heart failure. It is an effective diuretic not only when given intramuscularly and intravenously but also when given subcutaneously.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Congestive Heart Failure 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18137278 http://circ.ahajournals.org/content/1/4/502	Palliative		Not Provided 511	Thiomerin Approved Use Unknown

PubMed

Title	Date	PubMed
A trial of mercaptomerin in severe congestive heart failure.	1954-08-14	13182225
Clinical studies on thiomerin, a new mercurial diuretic.	1949-09	18139576
The subcutaneous administration of mercaptomerin; effective mercurial diuretic for the treatment of congestive heart failure.	1949-08-20	18137278
Treatment of myocardial failure; studies of a new and safe diuretic, thiomerin.	1949-02	18123664

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:49:18 GMT 2025` Edited by `admin` on `Mon Mar 31 17:49:18 GMT 2025`
Record UNII	06U2KLM373
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MERCAPTOMERIN SODIUM

Common Name

English

DIUCARDYN SODIUM

Preferred Name

English

LETORIN

Brand Name

English

DISODIUM N-(3-(CARBOXYMETHYLTHIOMERCURI)-2-METHOXYPROPYL)-.ALPHA.-CAMPHORAMATE

Common Name

English

SODIUM MERCAPTOMERIN

Common Name

English

N-(.GAMMA.-CARBOXYMETHYLMERCAPTOMERCURI-.BETA.-METHOXY)PROPYLCAMPHORAMIC ACID DISODIUM SALT

Common Name

English

Mercaptomerin sodium [WHO-DD]

Common Name

English

MERCAPTOMERIN SODIUM [MI]

Common Name

English

MERCURATE(2-), (3-(((3-CARBOXYLATO-2,2,3-TRIMETHYLCYCLOPENTYL)CARBONYL-.KAPPA.O)AMINO)-2-METHOXYPROPYL-.KAPPA.C)(2-(MERCAPTO-.KAPPA.S)ACETATO(2-)-.KAPPA.O)-, SODIUM (1:2), (T-4)-

Common Name

English

MERCURY, (3-(((3-CARBOXY-2,2,3-TRIMETHYLCYCLOPENTYL)CARBONYL)AMINO)-2-METHOXYPROPYL)(MERCAPTOACETATO-S)-, DISODIUM SALT

Common Name

English

CYCLOPENTANECARBOXYLIC ACID, 3-(((2-METHOXYPROPYL)AMINO)CARBONYL)-1,2,2-TRIMETHYL-, MERCURY COMPLEX

Common Name

English

THIOMERIN SODIUM

Brand Name

English

[3-(3-Carboxy-2,2,3-trimethylcyclopentanecarboxamido)-2-methoxypropyl](hydrogen mercaptoacetato)mercury disodium salt

Common Name

English

(T-4)-(3-(((3-CARBOXYLATO-2,2,3-TRIMETHYLCYCLOPENTYL)CARBONYL)AMINO)-2-METHOXYPROPYL)(MERCAPTOACETATO(2-)-O,S)MERCURATE(2-) DISODIUM

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID801016486