Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C40H65O13.K |
Molecular Weight | 793.0346 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 17 / 17 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[K+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]2(C)CC[C@@]([H])(O2)[C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@]([H])(O4)[C@@H](C)[C@@H](OC(=O)CC)[C@H](C)C([O-])=O)O3)[C@@]5([H])O[C@@](O)(COC(=O)CC)[C@H](C)C[C@@H]5C
InChI
InChIKey=OXNOQXLCECXEBU-QGMAIPBJSA-M
InChI=1S/C40H66O13.K/c1-11-30(42)47-20-40(46)23(5)17-21(3)32(52-40)28-18-22(4)35(48-28)38(10)14-13-29(50-38)37(9)15-16-39(53-37)19-27(41)24(6)34(51-39)25(7)33(26(8)36(44)45)49-31(43)12-2;/h21-29,32-35,41,46H,11-20H2,1-10H3,(H,44,45);/q;+1/p-1/t21-,22-,23+,24+,25-,26-,27-,28+,29+,32-,33+,34-,35+,37-,38-,39+,40-;/m0./s1
Laidlomycin is a polycyclic polyether antibiotic which possesses an inhibitory activity against various mycoplasma species}, and is effective in controlling coccidiosis in chickens. It is also known as selectively inhibiting the
migration of hemagglutinin glycoprotein from Golgi apparatus to the cell surface in measles virus). Laidlomycin inhibited growth of some Gram-positive bacteria only at high concentrations such as 50-100 ug/ml,
but was not active against Gram-negative bacteria,
yeast and fungi even at concentration of 1,000 ug/ml. In broth dilution, laidlomycin was active against several illycoplasmas and most active against the sterol-nonrequiring mycoplasma, Acholeplasma laidlawii. Under the brand name Cattlyst Laidlomycin is indicated for improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL378 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11099233 |
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Target ID: CHEMBL612313 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9814916 |
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Target ID: GO:0006811 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
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Primary | Cattlyst Approved UseFor improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter Launch Date1994 |
PubMed
Title | Date | PubMed |
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Intake, digestion, and digestive characteristics of Neotyphodium coenophialum-infected and uninfected fescue by heifers offered hay diets supplemented with Aspergillus oryzae fermentation extract or laidlomycin propionate. | 2002 Jan |
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Effects of the antibiotic ionophores monensin, lasalocid, laidlomycin propionate and bambermycin on Salmonella and E. coli O157:H7 in vitro. | 2003 |
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Ionophores have limited effects on jejunal glucose absorption and energy metabolism in mice. | 2003 Aug |
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Effect of feeding the ionophores monensin and laidlomycin propionate and the antimicrobial bambermycin to sheep experimentally infected with E. coli O157:H7 and Salmonella typhimurium. | 2003 Feb |
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Ionophores: their use as ruminant growth promotants and impact on food safety. | 2003 Sep |
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Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations. | 2004 Apr-Jun |
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Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684. | 2007 Feb |
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Monoclonal antibody production and immunochemical detection of polyether antibiotics. | 2009 Mar |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.betterchem.com/vet/laidlomycin.htm
Laidlomycin propionate promix, 50 g of laidlomycin propionate potassium per pound. Laidlomycin propionate premix should be admixed into feed and fed at a dietary concentration of 5 to 10 g of laidlomycin propionate/ton of feed (90% dry matter basis) to provide not less than 30 nor more than 150 mg/animal/day.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12926789
Laidlomycin propionate (16.2 mM) decreased (P < 0.02) glucose absorption, as estimated by H3-3-O-methyl glucose uptake compared with all other treatments of murine jejunal rings, whereas laidlomycin propionate (1.62 mM) increased (P = 0.032) jejunal DM content compared with 16.2 mM laidlomycin propionate.
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NCI_THESAURUS |
C258
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C79534
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AA-103
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m6667
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DTXSID001005083
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1306103
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CHEMBL2110869
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05TAA9I0Z8
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84799-02-0
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ACTIVE MOIETY
SUBSTANCE RECORD