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Details

Stereochemistry ABSOLUTE
Molecular Formula C40H65O13.K
Molecular Weight 793.0346
Optical Activity UNSPECIFIED
Defined Stereocenters 17 / 17
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LAIDLOMYCIN PROPIONATE POTASSIUM

SMILES

[K+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]2(C)CC[C@@]([H])(O2)[C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@]([H])(O4)[C@@H](C)[C@@H](OC(=O)CC)[C@H](C)C([O-])=O)O3)[C@@]5([H])O[C@@](O)(COC(=O)CC)[C@H](C)C[C@@H]5C

InChI

InChIKey=OXNOQXLCECXEBU-QGMAIPBJSA-M
InChI=1S/C40H66O13.K/c1-11-30(42)47-20-40(46)23(5)17-21(3)32(52-40)28-18-22(4)35(48-28)38(10)14-13-29(50-38)37(9)15-16-39(53-37)19-27(41)24(6)34(51-39)25(7)33(26(8)36(44)45)49-31(43)12-2;/h21-29,32-35,41,46H,11-20H2,1-10H3,(H,44,45);/q;+1/p-1/t21-,22-,23+,24+,25-,26-,27-,28+,29+,32-,33+,34-,35+,37-,38-,39+,40-;/m0./s1

HIDE SMILES / InChI
Laidlomycin is a polycyclic polyether antibiotic which possesses an inhibitory activity against various mycoplasma species}, and is effective in controlling coccidiosis in chickens. It is also known as selectively inhibiting the migration of hemagglutinin glycoprotein from Golgi apparatus to the cell surface in measles virus). Laidlomycin inhibited growth of some Gram-positive bacteria only at high concentrations such as 50-100 ug/ml, but was not active against Gram-negative bacteria, yeast and fungi even at concentration of 1,000 ug/ml. In broth dilution, laidlomycin was active against several illycoplasmas and most active against the sterol-nonrequiring mycoplasma, Acholeplasma laidlawii. Under the brand name Cattlyst Laidlomycin is indicated for improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Cattlyst

Approved Use

For improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter

Launch Date

1994
PubMed

PubMed

TitleDatePubMed
Intake, digestion, and digestive characteristics of Neotyphodium coenophialum-infected and uninfected fescue by heifers offered hay diets supplemented with Aspergillus oryzae fermentation extract or laidlomycin propionate.
2002 Jan
Effects of the antibiotic ionophores monensin, lasalocid, laidlomycin propionate and bambermycin on Salmonella and E. coli O157:H7 in vitro.
2003
Ionophores have limited effects on jejunal glucose absorption and energy metabolism in mice.
2003 Aug
Effect of feeding the ionophores monensin and laidlomycin propionate and the antimicrobial bambermycin to sheep experimentally infected with E. coli O157:H7 and Salmonella typhimurium.
2003 Feb
Ionophores: their use as ruminant growth promotants and impact on food safety.
2003 Sep
Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations.
2004 Apr-Jun
Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684.
2007 Feb
Monoclonal antibody production and immunochemical detection of polyether antibiotics.
2009 Mar
Patents

Sample Use Guides

Laidlomycin propionate promix, 50 g of laidlomycin propionate potassium per pound. Laidlomycin propionate premix should be admixed into feed and fed at a dietary concentration of 5 to 10 g of laidlomycin propionate/ton of feed (90% dry matter basis) to provide not less than 30 nor more than 150 mg/animal/day.
Route of Administration: Oral
Laidlomycin propionate (16.2 mM) decreased (P < 0.02) glucose absorption, as estimated by H3-3-O-methyl glucose uptake compared with all other treatments of murine jejunal rings, whereas laidlomycin propionate (1.62 mM) increased (P = 0.032) jejunal DM content compared with 16.2 mM laidlomycin propionate.
Name Type Language
LAIDLOMYCIN PROPIONATE POTASSIUM
GREEN BOOK   MI   USAN  
USAN  
Official Name English
RS-11988
Code English
MONENSIN, 16-DEETHYL-3-O-DEMETHYL-16-METHYL-3-O-(1-OXOPROPYL)-, 26-PROPANOATE, MONOPOTASSIUM SALT
Common Name English
LAIDLOMYCIN PROPIONATE POTASSIUM [MI]
Common Name English
LAIDLOMYCIN PROPIONATE POTASSIUM [USAN]
Common Name English
LAIDLOMYCIN PROPIONATE POTASSIUM [GREEN BOOK]
Common Name English
POTASSIUM LAIDLOMYCIN PROPANOATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C258
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C79534
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
USAN
AA-103
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
MERCK INDEX
m6667
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY Merck Index
PUBCHEM
23674236
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EPA CompTox
DTXSID001005083
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FDA UNII
05TAA9I0Z8
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RXCUI
1306103
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL2110869
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DAILYMED
05TAA9I0Z8
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
CAS
84799-02-0
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY