LAIDLOMYCIN PROPIONATE POTASSIUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C40H65O13.K
Molecular Weight	793.0346
Optical Activity	UNSPECIFIED
Defined Stereocenters	17 / 17
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LAIDLOMYCIN PROPIONATE POTASSIUM

Structure Search

SMILES

[K+].CCC(=O)OC[C@]1(O)O[C@H]([C@H]2C[C@H](C)[C@@H](O2)[C@]3(C)CC[C@@H](O3)[C@]4(C)CC[C@]5(C[C@H](O)[C@@H](C)[C@H](O5)[C@@H](C)[C@@H](OC(=O)CC)[C@H](C)C([O-])=O)O4)[C@@H](C)C[C@H]1C

InChI

InChIKey=OXNOQXLCECXEBU-QGMAIPBJSA-M

InChI=1S/C40H66O13.K/c1-11-30(42)47-20-40(46)23(5)17-21(3)32(52-40)28-18-22(4)35(48-28)38(10)14-13-29(50-38)37(9)15-16-39(53-37)19-27(41)24(6)34(51-39)25(7)33(26(8)36(44)45)49-31(43)12-2;/h21-29,32-35,41,46H,11-20H2,1-10H3,(H,44,45);/q;+1/p-1/t21-,22-,23+,24+,25-,26-,27-,28+,29+,32-,33+,34-,35+,37-,38-,39+,40-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C40H65O13
Molecular Weight	753.9363
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	17 / 17
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/pro/cattlyst.html | https://www.fda.gov/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm132769.htm | https://www.ncbi.nlm.nih.gov/pubmed/11099233 | https://www.ncbi.nlm.nih.gov/pubmed/4452661

Laidlomycin is a polycyclic polyether antibiotic which possesses an inhibitory activity against various mycoplasma species}, and is effective in controlling coccidiosis in chickens. It is also known as selectively inhibiting the migration of hemagglutinin glycoprotein from Golgi apparatus to the cell surface in measles virus). Laidlomycin inhibited growth of some Gram-positive bacteria only at high concentrations such as 50-100 ug/ml, but was not active against Gram-negative bacteria, yeast and fungi even at concentration of 1,000 ug/ml. In broth dilution, laidlomycin was active against several illycoplasmas and most active against the sterol-nonrequiring mycoplasma, Acholeplasma laidlawii. Under the brand name Cattlyst Laidlomycin is indicated for improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Human immunodeficiency virus 1 34 Target ID: CHEMBL378 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11099233	Inhibitor 8504
Streptococcus 2 Target ID: CHEMBL612313 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9814916	Inhibitor 8504
ion transport 4 Target ID: GO:0006811 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9814916 \| https://www.ncbi.nlm.nih.gov/pubmed/14503688	Activator 1447

Conditions

Condition	Modality	Targets	Highest Phase	Product
HIV-1 infection 156 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11099233	Primary		Basic research	Unknown Approved Use Unknown
Growth and weight problems in cattle 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10682819 https://www.ncbi.nlm.nih.gov/pubmed/8586605	Primary		Approved 8583	Cattlyst Approved Use For improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter Launch Date 1994

PubMed

Title	Date	PubMed
Monoclonal antibody production and immunochemical detection of polyether antibiotics.	2009-03	19387589
Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684.	2007-02	17342048
Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations.	2004-07-31	15283418
Ionophores: their use as ruminant growth promotants and impact on food safety.	2003-09	14503688
Ionophores have limited effects on jejunal glucose absorption and energy metabolism in mice.	2003-08	12926789
Effect of feeding the ionophores monensin and laidlomycin propionate and the antimicrobial bambermycin to sheep experimentally infected with E. coli O157:H7 and Salmonella typhimurium.	2003-02	12643501
Effects of the antibiotic ionophores monensin, lasalocid, laidlomycin propionate and bambermycin on Salmonella and E. coli O157:H7 in vitro.	2003	12534812
Intake, digestion, and digestive characteristics of Neotyphodium coenophialum-infected and uninfected fescue by heifers offered hay diets supplemented with Aspergillus oryzae fermentation extract or laidlomycin propionate.	2002-01	11831521

Patents

Sample Use Guides

In Vivo Use Guide

Laidlomycin propionate promix, 50 g of laidlomycin propionate potassium per pound. Laidlomycin propionate premix should be admixed into feed and fed at a dietary concentration of 5 to 10 g of laidlomycin propionate/ton of feed (90% dry matter basis) to provide not less than 30 nor more than 150 mg/animal/day.

Route of Administration: Oral

In Vitro Use Guide

Laidlomycin propionate (16.2 mM) decreased (P < 0.02) glucose absorption, as estimated by H3-3-O-methyl glucose uptake compared with all other treatments of murine jejunal rings, whereas laidlomycin propionate (1.62 mM) increased (P = 0.032) jejunal DM content compared with 16.2 mM laidlomycin propionate.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:33:41 GMT 2025` Edited by `admin` on `Mon Mar 31 18:33:41 GMT 2025`
Record UNII	05TAA9I0Z8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RS-11988

Preferred Name

English

LAIDLOMYCIN PROPIONATE POTASSIUM

Official Name

English

MONENSIN, 16-DEETHYL-3-O-DEMETHYL-16-METHYL-3-O-(1-OXOPROPYL)-, 26-PROPANOATE, MONOPOTASSIUM SALT

Common Name

English

LAIDLOMYCIN PROPIONATE POTASSIUM [MI]

Common Name

English

LAIDLOMYCIN PROPIONATE POTASSIUM [USAN]

Common Name

English

LAIDLOMYCIN PROPIONATE POTASSIUM [GREEN BOOK]

Common Name

English

POTASSIUM LAIDLOMYCIN PROPANOATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C258