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Details

Stereochemistry ABSOLUTE
Molecular Formula C40H65O13.K
Molecular Weight 793.0346
Optical Activity UNSPECIFIED
Defined Stereocenters 17 / 17
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LAIDLOMYCIN PROPIONATE POTASSIUM

SMILES

[K+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]2(C)CC[C@@]([H])(O2)[C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@]([H])(O4)[C@@H](C)[C@@H](OC(=O)CC)[C@H](C)C([O-])=O)O3)[C@@]5([H])O[C@@](O)(COC(=O)CC)[C@H](C)C[C@@H]5C

InChI

InChIKey=OXNOQXLCECXEBU-QGMAIPBJSA-M
InChI=1S/C40H66O13.K/c1-11-30(42)47-20-40(46)23(5)17-21(3)32(52-40)28-18-22(4)35(48-28)38(10)14-13-29(50-38)37(9)15-16-39(53-37)19-27(41)24(6)34(51-39)25(7)33(26(8)36(44)45)49-31(43)12-2;/h21-29,32-35,41,46H,11-20H2,1-10H3,(H,44,45);/q;+1/p-1/t21-,22-,23+,24+,25-,26-,27-,28+,29+,32-,33+,34-,35+,37-,38-,39+,40-;/m0./s1

HIDE SMILES / InChI

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C40H65O13
Molecular Weight 753.9363
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 17 / 17
E/Z Centers 0
Optical Activity UNSPECIFIED

Laidlomycin is a polycyclic polyether antibiotic which possesses an inhibitory activity against various mycoplasma species}, and is effective in controlling coccidiosis in chickens. It is also known as selectively inhibiting the migration of hemagglutinin glycoprotein from Golgi apparatus to the cell surface in measles virus). Laidlomycin inhibited growth of some Gram-positive bacteria only at high concentrations such as 50-100 ug/ml, but was not active against Gram-negative bacteria, yeast and fungi even at concentration of 1,000 ug/ml. In broth dilution, laidlomycin was active against several illycoplasmas and most active against the sterol-nonrequiring mycoplasma, Acholeplasma laidlawii. Under the brand name Cattlyst Laidlomycin is indicated for improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Cattlyst

Approved Use

For improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter

Launch Date

1994
PubMed

PubMed

TitleDatePubMed
Ionophores have limited effects on jejunal glucose absorption and energy metabolism in mice.
2003 Aug
Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations.
2004 Apr-Jun
Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684.
2007 Feb
Patents

Sample Use Guides

Laidlomycin propionate promix, 50 g of laidlomycin propionate potassium per pound. Laidlomycin propionate premix should be admixed into feed and fed at a dietary concentration of 5 to 10 g of laidlomycin propionate/ton of feed (90% dry matter basis) to provide not less than 30 nor more than 150 mg/animal/day.
Route of Administration: Oral
Laidlomycin propionate (16.2 mM) decreased (P < 0.02) glucose absorption, as estimated by H3-3-O-methyl glucose uptake compared with all other treatments of murine jejunal rings, whereas laidlomycin propionate (1.62 mM) increased (P = 0.032) jejunal DM content compared with 16.2 mM laidlomycin propionate.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:39:19 GMT 2023
Edited
by admin
on Fri Dec 15 16:39:19 GMT 2023
Record UNII
05TAA9I0Z8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LAIDLOMYCIN PROPIONATE POTASSIUM
GREEN BOOK   MI   USAN  
USAN  
Official Name English
RS-11988
Code English
MONENSIN, 16-DEETHYL-3-O-DEMETHYL-16-METHYL-3-O-(1-OXOPROPYL)-, 26-PROPANOATE, MONOPOTASSIUM SALT
Common Name English
LAIDLOMYCIN PROPIONATE POTASSIUM [MI]
Common Name English
LAIDLOMYCIN PROPIONATE POTASSIUM [USAN]
Common Name English
LAIDLOMYCIN PROPIONATE POTASSIUM [GREEN BOOK]
Common Name English
POTASSIUM LAIDLOMYCIN PROPANOATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C258
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C79534
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
USAN
AA-103
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
MERCK INDEX
m6667
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY Merck Index
PUBCHEM
23674236
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
EPA CompTox
DTXSID001005083
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
FDA UNII
05TAA9I0Z8
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
RXCUI
1306103
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL2110869
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
DAILYMED
05TAA9I0Z8
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
CAS
84799-02-0
Created by admin on Fri Dec 15 16:39:19 GMT 2023 , Edited by admin on Fri Dec 15 16:39:19 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY