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Details

Stereochemistry ACHIRAL
Molecular Formula C17H20N2O2S.ClH
Molecular Weight 352.879
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TINORIDINE HYDROCHLORIDE

SMILES

Cl.CCOC(=O)C1=C(N)SC2=C1CCN(CC3=CC=CC=C3)C2

InChI

InChIKey=LMAQHEGFQZGATE-UHFFFAOYSA-N
InChI=1S/C17H20N2O2S.ClH/c1-2-21-17(20)15-13-8-9-19(11-14(13)22-16(15)18)10-12-6-4-3-5-7-12;/h3-7H,2,8-11,18H2,1H3;1H

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: http://www.obatapasaja.com/2015/05/komposisi-dosis-dan-harga-nonflamin.html http://www.ncbi.nlm.nih.gov/pubmed/702946

Tinoridine is a non-steroidal anti-inflammatory and analgesic agent. This agent has been proved pharmacologically to show antiedematous and analgesic actions. The mechanism of the anti-inflammatory action of Tinoridine is attributed to its biomembrane stabilizing action particularly on the lysosomes which are related to cell or tissue damage at the time of inflammation through the release of hydrolytic enzymes. Tinoridine may produce gastrointestinal disorders (nausea, loss of appetite, diarrhea, and constipation), vertigo drowsiness, dry mouth and itching.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Nonflamin

Approved Use

Tinoridine is indicated as anti-inflammatory agent after surgery injuries or injury in urology.
Primary
Nonflamin

Approved Use

Tinoridine is used to treat pharyngitis, laryngitis, tonsillitis.
Primary
Nonflamin

Approved Use

For analgesic purpose, Tinoridine is used to treat back pain.
Primary
Nonflamin

Approved Use

For analgesic purpose, Tinoridine is used to treat lumbago.
Primary
Nonflamin

Approved Use

Tinoridine is indicated to treat pain in chronic rheumatic diseases.
PubMed

PubMed

TitleDatePubMed
Ethyl 2-amino-6-benzyl-4,5,6,7-tetra-hydro-thieno[2,3-c]pyridine-3-carboxyl-ate.
2010 Dec 24
Patents

Patents

Sample Use Guides

1-2 capsules 3 times a day
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Tinoridine, at concentrations from 5 microM up to 100 microM, produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 microM ascorbic acid in the renin granule fraction. http://www.ncbi.nlm.nih.gov/pubmed/3906080
30 uM of Tinoridine HCl hydrochloride inhibited the Phospholipase C-induced lysosomal enzyme release from rat liver lysosomes.
Name Type Language
TINORIDINE HYDROCHLORIDE
JAN   MART.   MI   WHO-DD  
Common Name English
Y-3642 HYDROCHLORIDE
Code English
ETHYL 2-AMINO-6-BENZYL-4,5,6,7-TETRAHYDROTHIENO(2,3-C)PYRIDINE-3-CARBOXYLATE HYDROCHLORIDE
Systematic Name English
Tinoridine hydrochloride [WHO-DD]
Common Name English
TINORIDINE HYDROCHLORIDE [JAN]
Common Name English
DIMATEN
Brand Name English
TINORIDINE HYDROCHLORIDE [MART.]
Common Name English
NONFLAMIN
Brand Name English
TINORIDINE HYDROCHLORIDE [MI]
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID60947048
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
SMS_ID
100000084609
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
ECHA (EC/EINECS)
246-103-6
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
ALTERNATIVE
CAS
24237-55-6
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
NON-SPECIFIC STOICHIOMETRY
DRUG BANK
DBSALT002331
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
MERCK INDEX
m1263
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY Merck Index
EVMPD
SUB04880MIG
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
ChEMBL
CHEMBL592943
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
FDA UNII
05IIB89IVA
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
ECHA (EC/EINECS)
247-342-9
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
MESH
C100290
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
CAS
25913-34-2
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY
PUBCHEM
134896
Created by admin on Fri Dec 15 18:47:55 GMT 2023 , Edited by admin on Fri Dec 15 18:47:55 GMT 2023
PRIMARY