Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H20N2S |
| Molecular Weight | 284.419 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(CN(C)C)N1C2=CC=CC=C2SC3=C1C=CC=C3
InChI
InChIKey=CGNHCKZJGQDWBG-UHFFFAOYSA-N
InChI=1S/C17H20N2S/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants. | 2003-05 |
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| The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers. | 2003-04 |
|
| Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. | 2003-04 |
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| Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. | 2003-04 |
|
| Clinical practice. Vestibular neuritis. | 2003-03-13 |
|
| Phenothiazine radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase: enzyme protection by radical scavengers. | 2003-03 |
|
| Effect of some psychotropic drugs on luminol-dependent chemiluminescence induced by O2-, *OH, HOCl. | 2003-02-04 |
|
| Inactivation of cholinesterase induced by chlorpromazine cation radicals. | 2003-02 |
|
| Effect of phenothiazines on protein kinase C- and calcium-dependent activation of peritoneal macrophages. | 2003-02 |
|
| Interaction between various resistance modifiers and apoptosis inducer 12H-benzo[alpha]phenothiazine. | 2003-01-18 |
|
| Reye's syndrome: down but not out. | 2003-01 |
|
| Interaction of carbamazepine and promethazine in rabbits. | 2003-01 |
|
| In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure. | 2003-01 |
|
| Antiemetic use in pediatric gastroenteritis: a national survey of emergency physicians, pediatricians, and pediatric emergency physicians. | 2002-12-05 |
|
| A systematic approach to the management of postoperative nausea and vomiting. | 2002-12 |
|
| Fibromyositis after intramuscular pentazocine abuse. | 2002-11-15 |
|
| TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243]. | 2002-10-16 |
|
| Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. | 2002-10 |
|
| Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine. | 2002-10 |
|
| Acute allergic reaction following contact with a spider. | 2002-10 |
|
| Enantioseparation of phenothiazines in cyclodextrin-modified micellar electrokinetic chromatography. | 2002-09-20 |
|
| Project USAP 2000--use of sedative agents by pediatric dentists: a 15-year follow-up survey. | 2002-09-06 |
|
| [Landau-Kleffner and autistic regression: the importance of differential diagnosis]. | 2002-09 |
|
| A case of homicide by lethal injection with lidocaine. | 2002-09 |
|
| Recovery, enrichment and selectivity in liquid-phase microextraction comparison with conventional liquid-liquid extraction. | 2002-07-19 |
|
| Bradykinin is involved in hyperalgesia induced by Bothrops jararaca venom. | 2002-07 |
|
| Simultaneous determination of promethazine, chlorpromazine, and perphenazine by multivariate calibration methods and derivative spectrophotometry. | 2002-06-27 |
|
| Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay. | 2002-06-19 |
|
| In vitro reversal of chloroquine resistance in Plasmodium falciparum with dihydroethanoanthracene derivatives. | 2002-06 |
|
| Indirect spectrophotometric determination of propranolol hydrochloride and piroxicam in pure and pharmaceutical formulations. | 2002-06 |
|
| Central effects of cinnarizine: restricted use in aircrew. | 2002-06 |
|
| Next generation antihistamines: therapeutic rationale, accomplishments and advances. | 2002-06 |
|
| Investigation of interaction of promethazine with cyclodextrins. | 2002-05-25 |
|
| Interaction of protonated anticancer thiazines with water-insoluble phospholipids and antineoplastic agents. | 2002-05-17 |
|
| Liquid-phase microextraction of protein-bound drugs under non-equilibrium conditions. | 2002-05 |
|
| Anxiolytic premedication reduces preoperative anxiety and pain during oocyte retrieval. A randomized double-blinded placebo-controlled trial. | 2002-05 |
|
| Study of the stability of promethazine enantiomers by liquid chromatography using a vancomycin-bonded chiral stationary phase. | 2002-04-25 |
|
| Investigation of the effect of tablet surface area/volume on drug release from hydroxypropylmethylcellulose controlled-release matrix tablets. | 2002-04 |
|
| Immunoassay screening of lysergic acid diethylamide (LSD) and its confirmation by HPLC and fluorescence detection following LSD ImmunElute extraction. | 2002-04 |
|
| [Validation of the HPLC method in the determination of dioxopromethazine and phenylephrine in eye drops]. | 2002-03 |
|
| Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes. | 2002-02 |
|
| An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers. | 2002-01 |
|
| [A case of fluvoxamine overdose]. | 2002-01 |
|
| [The activity of enzymes and free radical oxidation in acute and chronic fetal hypoxia in general anesthesia during cesarean section]. | 2002 |
|
| Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. | 2002 |
|
| [Suicidal attempts with old (currently unused) drug]. | 2002 |
|
| Antiallergic anti-inflammatory effects of H1-antihistamines in humans. | 2002 |
|
| Antihistamine antinociception is mediated by Gi-protein activation. | 2002 |
|
| [Work time distribution in night shift: are clinics facing a adjustment boom?]. | 2001-07 |
|
| The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare. | 2001 |
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044033O3TY
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3761
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ISOPROMETHAZINE
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DTXSID10952662
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110669
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100000077371
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m786
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SUB14277MIG
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303-14-0
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ACTIVE MOIETY
