ISOPROMETHAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20N2S
Molecular Weight	284.419
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CN(C)C)N1C2=C(SC3=C1C=CC=C3)C=CC=C2

InChI

InChIKey=CGNHCKZJGQDWBG-UHFFFAOYSA-N

InChI=1S/C17H20N2S/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare.	2001	11922397
A new goldfish model to evaluate pharmacokinetic and pharmacodynamic effects of drugs used for motion sickness in different gravity loads.	2001 Aug-Nov	11669128
Spectrofluorometric determination of 2- and 10-disubstituted phenothiazines.	2001 Jul-Aug	11693725
Adverse reactions related to phenergan.	2001 May-Jun	11847866
The use of on-line and off-line chromatographic extraction techniques coupled with mass spectrometry for support of in vivo and in vitro assays in drug discovery.	2001 Nov	11899108
Standard treatment: the role of antihistamines.	2001 Nov	11764306
Eye exposure to squashed spiders.	2001 Oct 1	11700827
Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy.	2001 Sep	11605110
Enantioseparation of phenothiazines in capillary zone electrophoresis using cyclodextrins as chiral selectors.	2001 Sep 28	11681573
Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity.	2002	12244568
[Suicidal attempts with old (currently unused) drug].	2002	12184019
Antiallergic anti-inflammatory effects of H1-antihistamines in humans.	2002	12113215
Antihistamine antinociception is mediated by Gi-protein activation.	2002	11927163
Current practices in managing acutely disturbed patients at three hospitals in Rio de Janeiro-Brazil: a prevalence study.	2002	11860610
A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis.	2002 Apr	11919526
Toxicity of ethacrynic acid in isolated rat hepatocytes.	2002 Apr	11869877
Study of the stability of promethazine enantiomers by liquid chromatography using a vancomycin-bonded chiral stationary phase.	2002 Apr 25	12013245
Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes.	2002 Feb	11936702
Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents.	2002 Feb	11918832
[A case of fluvoxamine overdose].	2002 Jan	11977737
Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide.	2002 Jan 7	11857004
Bradykinin is involved in hyperalgesia induced by Bothrops jararaca venom.	2002 Jul	12076660
Project USAP 2000--use of sedative agents by pediatric dentists: a 15-year follow-up survey.	2002 Jul-Aug	12212869
In vitro reversal of chloroquine resistance in Plasmodium falciparum with dihydroethanoanthracene derivatives.	2002 Jun	12224571
[Validation of the HPLC method in the determination of dioxopromethazine and phenylephrine in eye drops].	2002 Mar	11928283
The effect of meperidine and promethazine on fetal heart rate indices during the active phase of labor.	2002 Mar	11908257
Treatment patterns of isolated benign headache in US emergency departments.	2002 Mar	11867972
Nanoparticles in plant extracts: influence of drugs on the formation of nanoparticles and precipitates in black tea infusions.	2002 Mar	11849911
Interaction of protonated anticancer thiazines with water-insoluble phospholipids and antineoplastic agents.	2002 Mar-Apr	12014679
Anxiolytic premedication reduces preoperative anxiety and pain during oocyte retrieval. A randomized double-blinded placebo-controlled trial.	2002 May	11980744
Simultaneous determination of promethazine, chlorpromazine, and perphenazine by multivariate calibration methods and derivative spectrophotometry.	2002 May-Jun	12083247
Effect of some psychotropic drugs on luminol-dependent chemiluminescence induced by O2-, *OH, HOCl.	2002 Nov-Dec	12562096
Antiemetic use in pediatric gastroenteritis: a national survey of emergency physicians, pediatricians, and pediatric emergency physicians.	2002 Nov-Dec	12462313
Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase.	2002 Oct	12419014
Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine.	2002 Oct	12396292
Acute allergic reaction following contact with a spider.	2002 Oct	12368120
TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].	2002 Oct 16	12383353
A case of homicide by lethal injection with lidocaine.	2002 Sep	12353561
Enantioseparation of phenothiazines in cyclodextrin-modified micellar electrokinetic chromatography.	2002 Sep 20	12350123
A comparative evaluation of oral midazolam with other sedatives as premedication in pediatric dentistry.	2002 Winter	11874008
The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers.	2003 Apr	12722962
Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view.	2003 Apr	12678691
Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol.	2003 Apr	12657913
Inactivation of cholinesterase induced by chlorpromazine cation radicals.	2003 Feb	12747580
Effect of phenothiazines on protein kinase C- and calcium-dependent activation of peritoneal macrophages.	2003 Feb	12661983
Reye's syndrome: down but not out.	2003 Jan	12602712
Interaction of carbamazepine and promethazine in rabbits.	2003 Jan	12583009
Phenothiazine radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase: enzyme protection by radical scavengers.	2003 Mar	12688423
Clinical practice. Vestibular neuritis.	2003 Mar 13	12637613
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.	2003 May	12727271

Patents

Name

Type

Language

ISOPROMETHAZINE

Common Name

English

FEN-BRIDAL

Brand Name

English

RP-4460

Code

English

PROTHIAZIN

Brand Name

English

PROMETHAZINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

N,N,.BETA.-TRIMETHYL-10H-PHENOTHIAZINE-10-ETHANAMINE

Systematic Name

English

10-(2-DIMETHYLAMINOISOPROPYL)PHENOTHIAZINE

Common Name

English

ISOPROMETHAZINE [MI]

Common Name

English

ISOMETHAZINE

Common Name

English

Isopromethazine [WHO-DD]

Common Name

English

LILLY-01526

Code

English

ISOPHENERGAN

Common Name

English

Code System Code Type Description

FDA UNII

044033O3TY