ISOPROMETHAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20N2S
Molecular Weight	284.419
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CN(C)C)N1C2=CC=CC=C2SC3=C1C=CC=C3

InChI

InChIKey=CGNHCKZJGQDWBG-UHFFFAOYSA-N

InChI=1S/C17H20N2S/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C17H20N2S
Molecular Weight	284.419
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

PubMed

Title	Date	PubMed
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.	2003-05	12727271
The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers.	2003-04	12722962
Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view.	2003-04	12678691
Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol.	2003-04	12657913
Clinical practice. Vestibular neuritis.	2003-03-13	12637613
Phenothiazine radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase: enzyme protection by radical scavengers.	2003-03	12688423
Effect of some psychotropic drugs on luminol-dependent chemiluminescence induced by O2-, *OH, HOCl.	2003-02-04	12562096
Inactivation of cholinesterase induced by chlorpromazine cation radicals.	2003-02	12747580
Effect of phenothiazines on protein kinase C- and calcium-dependent activation of peritoneal macrophages.	2003-02	12661983
Interaction between various resistance modifiers and apoptosis inducer 12H-benzo[alpha]phenothiazine.	2003-01-18	12530005
Reye's syndrome: down but not out.	2003-01	12602712
Interaction of carbamazepine and promethazine in rabbits.	2003-01	12583009
In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure.	2003-01	12444298
Antiemetic use in pediatric gastroenteritis: a national survey of emergency physicians, pediatricians, and pediatric emergency physicians.	2002-12-05	12462313
A systematic approach to the management of postoperative nausea and vomiting.	2002-12	12476402
Fibromyositis after intramuscular pentazocine abuse.	2002-11-15	12432208
TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].	2002-10-16	12383353
Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase.	2002-10	12419014
Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine.	2002-10	12396292
Acute allergic reaction following contact with a spider.	2002-10	12368120
Enantioseparation of phenothiazines in cyclodextrin-modified micellar electrokinetic chromatography.	2002-09-20	12350123
Project USAP 2000--use of sedative agents by pediatric dentists: a 15-year follow-up survey.	2002-09-06	12212869
[Landau-Kleffner and autistic regression: the importance of differential diagnosis].	2002-09	12364957
A case of homicide by lethal injection with lidocaine.	2002-09	12353561
Recovery, enrichment and selectivity in liquid-phase microextraction comparison with conventional liquid-liquid extraction.	2002-07-19	12187984
Bradykinin is involved in hyperalgesia induced by Bothrops jararaca venom.	2002-07	12076660
Simultaneous determination of promethazine, chlorpromazine, and perphenazine by multivariate calibration methods and derivative spectrophotometry.	2002-06-27	12083247
Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay.	2002-06-19	12052500
In vitro reversal of chloroquine resistance in Plasmodium falciparum with dihydroethanoanthracene derivatives.	2002-06	12224571
Indirect spectrophotometric determination of propranolol hydrochloride and piroxicam in pure and pharmaceutical formulations.	2002-06	12083553
Central effects of cinnarizine: restricted use in aircrew.	2002-06	12056673
Next generation antihistamines: therapeutic rationale, accomplishments and advances.	2002-06	12036424
Investigation of interaction of promethazine with cyclodextrins.	2002-05-25	12026112
Interaction of protonated anticancer thiazines with water-insoluble phospholipids and antineoplastic agents.	2002-05-17	12014679
Liquid-phase microextraction of protein-bound drugs under non-equilibrium conditions.	2002-05	12081037
Anxiolytic premedication reduces preoperative anxiety and pain during oocyte retrieval. A randomized double-blinded placebo-controlled trial.	2002-05	11980744
Study of the stability of promethazine enantiomers by liquid chromatography using a vancomycin-bonded chiral stationary phase.	2002-04-25	12013245
Investigation of the effect of tablet surface area/volume on drug release from hydroxypropylmethylcellulose controlled-release matrix tablets.	2002-04	12056539
Immunoassay screening of lysergic acid diethylamide (LSD) and its confirmation by HPLC and fluorescence detection following LSD ImmunElute extraction.	2002-04	11991536
[Validation of the HPLC method in the determination of dioxopromethazine and phenylephrine in eye drops].	2002-03	11928283
Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes.	2002-02	11936702
An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers.	2002-01	12002730
[A case of fluvoxamine overdose].	2002-01	11977737
[The activity of enzymes and free radical oxidation in acute and chronic fetal hypoxia in general anesthesia during cesarean section].	2002	12577498
Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity.	2002	12244568
[Suicidal attempts with old (currently unused) drug].	2002	12184019
Antiallergic anti-inflammatory effects of H1-antihistamines in humans.	2002	12113215
Antihistamine antinociception is mediated by Gi-protein activation.	2002	11927163
[Work time distribution in night shift: are clinics facing a adjustment boom?].	2001-07	12025123
The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare.	2001	11922397

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:38:44 GMT 2025` Edited by `admin` on `Mon Mar 31 18:38:44 GMT 2025`
Record UNII	044033O3TY
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FEN-BRIDAL

Preferred Name

English

ISOPROMETHAZINE

Common Name

English

RP-4460

Code

English

PROTHIAZIN

Brand Name

English

PROMETHAZINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

N,N,.BETA.-TRIMETHYL-10H-PHENOTHIAZINE-10-ETHANAMINE

Systematic Name

English

10-(2-DIMETHYLAMINOISOPROPYL)PHENOTHIAZINE

Common Name

English

ISOPROMETHAZINE [MI]

Common Name

English

ISOMETHAZINE

Common Name

English

Isopromethazine [WHO-DD]

Common Name

English

LILLY-01526

Code

English

ISOPHENERGAN

Common Name

English

Code System Code Type Description

FDA UNII

044033O3TY