HEXESTROL DIACETATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H26O4
Molecular Weight	354.4394
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@@H]([C@@H](CC)C1=CC=C(OC(C)=O)C=C1)C2=CC=C(OC(C)=O)C=C2

InChI

InChIKey=GWEREDCWIUZACS-SZPZYZBQSA-N

InChI=1S/C22H26O4/c1-5-21(17-7-11-19(12-8-17)25-15(3)23)22(6-2)18-9-13-20(14-10-18)26-16(4)24/h7-14,21-22H,5-6H2,1-4H3/t21-,22+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26527911 | https://www.genome.jp/dbget-bin/www_bget?drug+D02018 | https://www.academia.edu/31688636/HEXESTROL_DIACETATE-INDUCED_FOLLICULAR_ATRESIA_IN_IMPUBER_SHEEP | https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+2149

Hexestrol diacetate (brand name Retalon-Lingual among others) is an ester of hexestrol. It is a synthetic estrogen that was used for the treatment of menstruation disorder. It is an estrogen receptor agonist. A single therapeutic dose of hexestrol diacetate administered in impuber sheep has been shown to induce massive follicular atresia. So the incorrect utilisation of some hormonal formulations and the consumption of forages that contain estrogen like compounds, can represent major causes of infertility in sheep.

Approval Year

Sample Use Guides

In Vivo Use Guide

The rabbits were administered 0.5 mg/kg of body weight hexestrol diacetate intramuscularly twice a week for four consecutive weeks.

Route of Administration: Intramuscular

Name

Type

Language

HEXESTROL DIACETATE

Common Name

English

HEXESTROL DIACETATE [MI]

Common Name

English

SINTOFOLIN

Common Name

English

PHENOL,4,4'-((1R,2S)-1,2-DIETHYL-1,2-ETHANEDIYL)BIS-, DIACETATE, REL-

Common Name

English

Hexestrol diacetate [WHO-DD]

Common Name

English

DIACETYLHEXESTROL

Common Name

English

HEXESTROL DIACETATE [JAN]

Common Name

English

Code System Code Type Description

MESH

C558630