U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C22H26O4
Molecular Weight 354.4394
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEXESTROL DIACETATE

SMILES

CC[C@@H]([C@@H](CC)C1=CC=C(OC(C)=O)C=C1)C2=CC=C(OC(C)=O)C=C2

InChI

InChIKey=GWEREDCWIUZACS-SZPZYZBQSA-N
InChI=1S/C22H26O4/c1-5-21(17-7-11-19(12-8-17)25-15(3)23)22(6-2)18-9-13-20(14-10-18)26-16(4)24/h7-14,21-22H,5-6H2,1-4H3/t21-,22+

HIDE SMILES / InChI
Hexestrol diacetate (brand name Retalon-Lingual among others) is an ester of hexestrol. It is a synthetic estrogen that was used for the treatment of menstruation disorder. It is an estrogen receptor agonist. A single therapeutic dose of hexestrol diacetate administered in impuber sheep has been shown to induce massive follicular atresia. So the incorrect utilisation of some hormonal formulations and the consumption of forages that contain estrogen like compounds, can represent major causes of infertility in sheep.

Approval Year

Sample Use Guides

The rabbits were administered 0.5 mg/kg of body weight hexestrol diacetate intramuscularly twice a week for four consecutive weeks.
Route of Administration: Intramuscular
Name Type Language
HEXESTROL DIACETATE
JAN   MI   WHO-DD  
Common Name English
HEXESTROL DIACETATE [MI]
Common Name English
SINTOFOLIN
Common Name English
PHENOL,4,4'-((1R,2S)-1,2-DIETHYL-1,2-ETHANEDIYL)BIS-, DIACETATE, REL-
Common Name English
Hexestrol diacetate [WHO-DD]
Common Name English
DIACETYLHEXESTROL
Common Name English
HEXESTROL DIACETATE [JAN]
Common Name English
Code System Code Type Description
MESH
C558630
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY
EVMPD
SUB02511MIG
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY
PUBCHEM
656653
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY
CAS
4547-76-6
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY
MERCK INDEX
m6007
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY Merck Index
SMS_ID
100000086701
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY
FDA UNII
0432698UA0
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID701046436
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY
WIKIPEDIA
Hexestrol diacetate
Created by admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
PRIMARY