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Details

Stereochemistry ACHIRAL
Molecular Formula C22H26O4
Molecular Weight 354.4394
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEXESTROL DIACETATE

SMILES

CC[C@@H]([C@@H](CC)C1=CC=C(OC(C)=O)C=C1)C2=CC=C(OC(C)=O)C=C2

InChI

InChIKey=GWEREDCWIUZACS-SZPZYZBQSA-N
InChI=1S/C22H26O4/c1-5-21(17-7-11-19(12-8-17)25-15(3)23)22(6-2)18-9-13-20(14-10-18)26-16(4)24/h7-14,21-22H,5-6H2,1-4H3/t21-,22+

HIDE SMILES / InChI

Molecular Formula C22H26O4
Molecular Weight 354.4394
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Hexestrol diacetate (brand name Retalon-Lingual among others) is an ester of hexestrol. It is a synthetic estrogen that was used for the treatment of menstruation disorder. It is an estrogen receptor agonist. A single therapeutic dose of hexestrol diacetate administered in impuber sheep has been shown to induce massive follicular atresia. So the incorrect utilisation of some hormonal formulations and the consumption of forages that contain estrogen like compounds, can represent major causes of infertility in sheep.

Approval Year

Sample Use Guides

In Vivo Use Guide
The rabbits were administered 0.5 mg/kg of body weight hexestrol diacetate intramuscularly twice a week for four consecutive weeks.
Route of Administration: Intramuscular
Substance Class Chemical
Record UNII
0432698UA0
Record Status Validated (UNII)
Record Version