U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C28H36O6
Molecular Weight 468.5818
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLINOFIBRATE

SMILES

CCC(C)(OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(OC(C)(CC)C(O)=O)C=C3)C(O)=O

InChI

InChIKey=BMOVQUBVGICXQN-UHFFFAOYSA-N
InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)

HIDE SMILES / InChI
Clinofibrate is known as a fibrate therapeutic drug for hyperlipidemia.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q07869
Gene ID: 5465.0
Gene Symbol: PPARA
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LIPOCLIN

Approved Use

It is usually used to treat hyperlipidemia.
PubMed

PubMed

TitleDatePubMed
Effects of some hypolipidemic agents on biochemical values and hepatic peroxisomal enzymes in rats: comparison of probucol, CGA, KCD-232, MLM-160, AL-369 and clinofibrate with clofibrate.
1987 Mar
A case of familial hypercholesterolemia; secession from LDL-apheresis by the drug treatment with potent statin and resin.
2005 Sep
Flow cytometric evaluation of synergistic pro-apoptotic effects of statins and clofibrates in IM-9 human lymphoblasts.
2007 Sep
4,4'-(Cyclo-hexane-1,1-di-yl)diphenol methanol solvate.
2009 Jan 10
In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities.
2010 Dec
Patents

Patents

Sample Use Guides

For adults, take 1 tablet (200mg of the active ingredient) at a time, 3 times a day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
CLINOFIBRATE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
2,2'-(CYCLOHEXYLIDENEBIS(P-PHENYLENEOXY))BIS(2-METHYLBUTYRIC ACID)
Common Name English
CLINOFIBRATE [JAN]
Common Name English
Clinofibrate [WHO-DD]
Common Name English
clinofibrate [INN]
Common Name English
CLINOFIBRATE [MI]
Common Name English
CLINOFIBRATE [MART.]
Common Name English
LIPOCLIN
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C98150
Created by admin on Fri Dec 15 16:09:56 GMT 2023 , Edited by admin on Fri Dec 15 16:09:56 GMT 2023
Code System Code Type Description
EVMPD
SUB06666MIG
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PRIMARY
MESH
C006231
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PRIMARY
WIKIPEDIA
CLINOFIBRATE
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PRIMARY
ChEMBL
CHEMBL1897738
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DRUG CENTRAL
680
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DRUG BANK
DB09006
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NCI_THESAURUS
C78052
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PRIMARY
MERCK INDEX
m3625
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PRIMARY Merck Index
SMS_ID
100000084296
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PRIMARY
EPA CompTox
DTXSID6046638
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INN
4421
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PRIMARY
CAS
30299-08-2
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FDA UNII
0374EZJ8CU
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PUBCHEM
2787
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PRIMARY