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Details

Stereochemistry RACEMIC
Molecular Formula C15H22N2O2.CH4O3S
Molecular Weight 358.453
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DABELOTINE MESYLATE

SMILES

CS(O)(=O)=O.CN1CCCC2=C1C(OCC3CNCCO3)=CC=C2

InChI

InChIKey=RSEKRLGWBUABQM-UHFFFAOYSA-N
InChI=1S/C15H22N2O2.CH4O3S/c1-17-8-3-5-12-4-2-6-14(15(12)17)19-11-13-10-16-7-9-18-13;1-5(2,3)4/h2,4,6,13,16H,3,5,7-11H2,1H3;1H3,(H,2,3,4)

HIDE SMILES / InChI
Dabelotine is a cognitive-enhancing drug, developed by Servier. The drug has been shown to improve some aspects of cognitive processes, such as attention, curiosity, motivation, acquisition, and recall of memory. Dabelotine has also been shown to reduce the effect of an anticholinergic drug such as scopolamine. The drug increases the in vitro K+-induced norepinephrine release in rodent cerebral slices, and have no effect on noradrenergic and cholinergic receptor binding sites. Dabelotine was investigated in phase 2 clinical trials for the treatment of dementia, where it was demonstrated that 50-mg and 100-mg doses produced an improvement in reaction time and performance in memory tasks.

Approval Year

Patents
Name Type Language
DABELOTINE MESYLATE
Common Name English
S-12024-2
Preferred Name English
QUINOLINE, 1,2,3,4-TETRAHYDRO-1-METHYL-8-(2-MORPHOLINYLMETHOXY)-, METHANESULFONATE (1:1)
Systematic Name English
Code System Code Type Description
FDA UNII
03045W04DP
Created by admin on Mon Mar 31 23:45:53 GMT 2025 , Edited by admin on Mon Mar 31 23:45:53 GMT 2025
PRIMARY
CAS
153049-48-0
Created by admin on Mon Mar 31 23:45:53 GMT 2025 , Edited by admin on Mon Mar 31 23:45:53 GMT 2025
PRIMARY
PUBCHEM
177948
Created by admin on Mon Mar 31 23:45:53 GMT 2025 , Edited by admin on Mon Mar 31 23:45:53 GMT 2025
PRIMARY