Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C21H25NO3 |
| Molecular Weight | 339.4281 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN1CCCC(C1)OC(=O)C(O)(C2=CC=CC=C2)C3=CC=CC=C3
InChI
InChIKey=OJYOTLHNSMYONM-UHFFFAOYSA-N
InChI=1S/C21H25NO3/c1-2-22-15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19,24H,2,9,14-16H2,1H3
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14463342 | https://www.ncbi.nlm.nih.gov/pubmed/13616780
Curator's Comment: The most characteristic psychological
aspects of the JB 318 (N-ethyl-3-piperidyl-benzilate) reaction were self-preoccupation, self-imposed stereotypy of behavior, and a reduced awareness of the environment. The post-JB 318 hypomania was a sort
of emotional rebound phenomenon—a defensive reaction akin to counterphobic
mechanisms which consisted of denial and reaction formation.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Evaluation of PET ligands (+)N-[(11)C]ethyl-3-piperidyl benzilate and (+)N-[(11)C]propyl-3-piperidyl benzilate for muscarinic cholinergic receptors: a PET study with microdialysis in comparison with (+)N-[(11)C]methyl-3-piperidyl benzilate in the conscious monkey brain. | 2001 Jun 1 |
Patents
Sample Use Guides
N-Ethyl-3-piperidyl benzilate (JB-318) 15 mg were administered orally to 10 medical students
Route of Administration:
Oral
In order to determine whether perehlorie acid completely extracted
JB-318* from tissues, various amounts (1--10 ug) of JB-318* were added to aqueous homogenates of brain and kidney which were then incubated
at 0 degrees for 1 hour.
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DEA NO. |
7482
Created by
admin on Sat Dec 16 08:30:36 GMT 2023 , Edited by admin on Sat Dec 16 08:30:36 GMT 2023
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| Code System | Code | Type | Description | ||
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N-Ethyl-3-piperidyl benzilate
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02J52696MZ
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62504
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DTXSID20863199
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524174
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3567-12-2
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
