| Stereochemistry | ABSOLUTE |
| Molecular Formula | C7H12N2O4 |
| Molecular Weight | 188.1812 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)N[C@@H](CCC(N)=O)C(O)=O
InChI
InChIKey=KSMRODHGGIIXDV-YFKPBYRVSA-N
InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1
Aceglutamide (INN, JAN) (brand name Neuramina), or aceglutamide aluminum (JAN, USAN) (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. Aceglutamide functions as a prodrug to glutamine with improved potency and stability. Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition.
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Rat pheochromocytoma cell lines (PC12) were cultured in RPMI-1640 supplemented with 5% FBS and 10% HS, at 37◦C in a humidified atmosphere of 5% CO2 and 95% oxygen. The cells were incubated with Na2S2O4 at a final concentration of 10mM in the sugar and glutamine-free Earle’s solution for 4 h (hypoxia) and the cell solution was then replaced by normal medium without adding glutamine (reoxygenation). Series concentrations of Aceglutamide (0.01, 0.1, 1 and 10 mkM) were added into the culture medium 24 h after the onset of reoxygenation. Control cultures were treated in a similar way except the hypoxic challenge.
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
