ACEGLUTAMIDE ALUMINUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	5C7H11N2O4.3Al.4HO
Molecular Weight	1084.8402
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Al+3].CC(=O)N[C@@H](CCC(N)=O)C([O-])=O.CC(=O)N[C@@H](CCC(N)=O)C([O-])=O.CC(=O)N[C@@H](CCC(N)=O)C([O-])=O.CC(=O)N[C@@H](CCC(N)=O)C([O-])=O.CC(=O)N[C@@H](CCC(N)=O)C([O-])=O

InChI

InChIKey=IVVHAAOJLULJLK-YDXSIYMFSA-E

InChI=1S/5C7H12N2O4.3Al.4H2O/c5*1-4(10)9-5(7(12)13)2-3-6(8)11;;;;;;;/h5*5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13);;;;4*1H2/q;;;;;3*+3;;;;/p-9/t5*5-;;;;;;;/m00000......./s1

HIDE SMILES / InChI

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Al
Molecular Weight	26.9815
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H11N2O4
Molecular Weight	187.1732
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814209
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/aceglutamide.html | https://www.ncbi.nlm.nih.gov/pubmed/26444640 | https://www.ncbi.nlm.nih.gov/pubmed/1790087 | https://www.ncbi.nlm.nih.gov/pubmed/7274416

Aceglutamide (INN, JAN) (brand name Neuramina), or aceglutamide aluminum (JAN, USAN) (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. Aceglutamide functions as a prodrug to glutamine with improved potency and stability. Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Peptic ulcer 72 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1790087	Primary		Approved 8429	Neuramina Approved Use Unknown

PubMed

Title	Date	PubMed
N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs.	2007 Mar	17253138

Patents

Sample Use Guides

In Vivo Use Guide

700 mg bid

Route of Administration: Oral

In Vitro Use Guide

Rat pheochromocytoma cell lines (PC12) were cultured in RPMI-1640 supplemented with 5% FBS and 10% HS, at 37◦C in a humidified atmosphere of 5% CO2 and 95% oxygen. The cells were incubated with Na2S2O4 at a final concentration of 10mM in the sugar and glutamine-free Earle’s solution for 4 h (hypoxia) and the cell solution was then replaced by normal medium without adding glutamine (reoxygenation). Series concentrations of Aceglutamide (0.01, 0.1, 1 and 10 mkM) were added into the culture medium 24 h after the onset of reoxygenation. Control cultures were treated in a similar way except the hypoxic challenge.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:13:36 GMT 2023` Edited by `admin` on `Fri Dec 15 15:13:36 GMT 2023`
Record UNII	R7QTG0PMPX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACEGLUTAMIDE ALUMINUM

Official Name

English

KW 110

Code

English

N-ACETYL-L-GLUTAMINE ALUMINUM COMPLEX

Common Name

English

ACEGLUTAMIDE ALUMINUM COMPLEX [MI]

Common Name

English

(N(SUP 2)-ACETYL-L-GLUTAMINATO)TETRAHYDROXYTRIALUMINIUM

Common Name

English

GLUMAL

Brand Name

English

ACEGLUTAMIDE ALUMINUM [JAN]

Common Name

English

(N(SUP 2)-ACETYL-L-GLUTAMINATO)TETRAHYDROXYTRIALUMINUM

Common Name

English

ACEGLUTAMIDE ALUMINIUM [MART.]

Common Name

English

Aceglutamide aluminium [WHO-DD]

Common Name

English

PENTAKIS (N(SUP 2)-ACETYL-L-GLUTAMINATO)TETRAHYDROXYTRIALUMINUM

Common Name

English

ALUMINIUM, PENTAKIS(N(SUP 2)-ACETYL-L-GLUTAMINATO)TETRAHYDROXYTRI-

Common Name

English

ALUMINUM, PENTAKIS(N(SUP 2)-ACETYL-L-GLUTAMINATO)TETRAHYDROXYTRI-

Common Name

English

KW-110

Code

English

ACEGLUTAMIDE ALUMINUM COMPLEX

Common Name

English

ACEGLUTAMIDE ALUMINUM [USAN]

Common Name

English

N-ACETYL-L-GLUTAMINE ALUMINIUM COMPLEX

Common Name

English

PENTAKIS (N(SUP 2)-ACETYL-L-GLUTAMINATO)TETRAHYDROXYTRIALUMINIUM

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29701