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There is one exact (name or code) match for trilostane

TRILOSTANE

L0FPV48Q5R

Search for Structure

Status:

US Previously Marketed

Source:

MODRASTANE by BIOENVISION

(1984)

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=018719

First approved in 1984

Source:

MODRASTANE by BIOENVISION

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=018719

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II

3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

Conditions:

Post-menopausal breast cancer

Cushing’s disease

Conn’s syndrome

Pituitary-dependent hyperadrenocorticism

Trilostane is a synthetic steroid, which interferes with the formation of both cortisol and aldosterone. It is an inhibitor of 3 beta-hydroxysteroid dehydrogenase. This drug under trade name MODRASTANE was withdrawn from human use in the United States market. But marketed under the trade names Modrenal and is already approved in the United Kingdom for the treatment of advanced post-menopausal breast cancer and Cushing 's disease. In addition, this drug has been successfully developed and marketed for veterinary use in the United Kingdom under the trade name Vetoryl.

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TRILOSTANE

L0FPV48Q5R

Search for Structure

Status:

US Previously Marketed

Source:

MODRASTANE by BIOENVISION

(1984)

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=018719

First approved in 1984

Source:

MODRASTANE by BIOENVISION

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=018719

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II

3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

Conditions:

Post-menopausal breast cancer

Cushing’s disease

Conn’s syndrome

Pituitary-dependent hyperadrenocorticism

Trilostane is a synthetic steroid, which interferes with the formation of both cortisol and aldosterone. It is an inhibitor of 3 beta-hydroxysteroid dehydrogenase. This drug under trade name MODRASTANE was withdrawn from human use in the United States market. But marketed under the trade names Modrenal and is already approved in the United Kingdom for the treatment of advanced post-menopausal breast cancer and Cushing 's disease. In addition, this drug has been successfully developed and marketed for veterinary use in the United Kingdom under the trade name Vetoryl.

Structure of TRILOSTANE

ABSOLUTE

HHS VULNERABILITY DISCLOSURE

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