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Here are the exact (name or code) matches for rotigotine

ROTIGOTINE, (±)-

5QTR54Z0E1

Search for Structure

Status:

Investigational

Source:

NCT00389831: Phase 2 Interventional Completed Restless Legs Syndrome

(2006)

Source URL:

https://clinicaltrials.gov/ct2/show/NCT00389831

Class (Stereo):

CHEMICAL (RACEMIC)

ROTIGOTINE

87T4T8BO2E

Search for Structure

Status:

US Approved Rx (2007)

Source:

NDA021829

(2007)

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=021829

First approved in 2007

Source:

NDA021829

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=021829

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Dopamine D5 receptor

Dopamine D2 receptor

Dopamine D4 receptor

Dopamine D1 receptor

Dopamine D3 receptor

Serotonin 1a (5-HT1a) receptor

Alpha-2b adrenergic receptor

Conditions:

Restless legs syndrome

Parkinson's disease

Rotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity. It is also an antagonist at α-2-adrenergic receptors and an agonist at the 5HT1A receptors. Rotigotine also inhibits dopamine uptake and prolactin secretion. It is FDA approved for the treatment of Parkinson's disease, restless legs syndrome. Dopamine antagonists, such as antipsychotics or metoclopramide, may diminish the effectiveness of Rotigotine. Common adverse reactions include nausea, vomiting, somnolence, application site reactions, dizziness, anorexia, hyperhidrosis, insomnia and dyskinesia.

Showing 1 - 10 of 26 results

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ROTIGOTINE

87T4T8BO2E

Search for Structure

Status:

US Approved Rx (2007)

Source:

NDA021829

(2007)

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=021829

First approved in 2007

Source:

NDA021829

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=021829

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Dopamine D5 receptor

Dopamine D2 receptor

Dopamine D4 receptor

Dopamine D1 receptor

Dopamine D3 receptor

Serotonin 1a (5-HT1a) receptor

Alpha-2b adrenergic receptor

Conditions:

Restless legs syndrome

Parkinson's disease

Rotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity. It is also an antagonist at α-2-adrenergic receptors and an agonist at the 5HT1A receptors. Rotigotine also inhibits dopamine uptake and prolactin secretion. It is FDA approved for the treatment of Parkinson's disease, restless legs syndrome. Dopamine antagonists, such as antipsychotics or metoclopramide, may diminish the effectiveness of Rotigotine. Common adverse reactions include nausea, vomiting, somnolence, application site reactions, dizziness, anorexia, hyperhidrosis, insomnia and dyskinesia.

ROTIGOTINE, (±)-

5QTR54Z0E1

Search for Structure

Status:

Investigational

Source:

NCT00389831: Phase 2 Interventional Completed Restless Legs Syndrome

(2006)

Source URL:

https://clinicaltrials.gov/ct2/show/NCT00389831

Class (Stereo):

CHEMICAL (RACEMIC)

DESTHIENYLETHYL ROTIGOTINE SULFATE

C83X2N3S59

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

(6S)-6-(PROPYL(2-(THIOPHEN-2-YL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL ACETATE

97PH4652RU

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

DESPROPYL ROTIGOTINE

JG1Y5K2S3K

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

(2S)-5-HYDROXY-N-PROPYL-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE N-OXIDE

WB3G8JP37G

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (EPIMERIC)

(2S)-N-PROPYL-5-(2-(THIOPHEN-2-YL)ETHOXY)-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE

23QRX5CL2N

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

(6S)-6-(PROPYL(2-(THIOPHEN-2-YL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL 4-METHYLBENZENESULFONATE

HVH6S4SUP6

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

(S)-5-METHOXY-N-PROPYL-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE

F6E9QF4TQ0

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

(6S)-6-(ETHYL(2-(2-THIENYL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENOL

BX28WNZ8X5

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Structure of ROTIGOTINE

ABSOLUTE

Structure of ROTIGOTINE, (±)-

RACEMIC

ROTIGOTINE, (±)-

Structure of DESTHIENYLETHYL ROTIGOTINE SULFATE

ABSOLUTE

DESTHIENYLETHYL ROTIGOTINE SULFATE

Structure of (6S)-6-(PROPYL(2-(THIOPHEN-2-YL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL ACETATE

ABSOLUTE

(6S)-6-(PROPYL(2-(THIOPHEN-2-YL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL ACETATE

Structure of DESPROPYL ROTIGOTINE

ABSOLUTE

DESPROPYL ROTIGOTINE

Structure of (2S)-5-HYDROXY-N-PROPYL-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE N-OXIDE

EPIMERIC

(2S)-5-HYDROXY-N-PROPYL-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE N-OXIDE

Structure of (2S)-N-PROPYL-5-(2-(THIOPHEN-2-YL)ETHOXY)-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE

ABSOLUTE

(2S)-N-PROPYL-5-(2-(THIOPHEN-2-YL)ETHOXY)-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE

Structure of (6S)-6-(PROPYL(2-(THIOPHEN-2-YL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL 4-METHYLBENZENESULFONATE

ABSOLUTE

(6S)-6-(PROPYL(2-(THIOPHEN-2-YL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL 4-METHYLBENZENESULFONATE

Structure of (S)-5-METHOXY-N-PROPYL-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE

ABSOLUTE

(S)-5-METHOXY-N-PROPYL-N-(2-(THIOPHEN-2-YL)ETHYL)-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE

Structure of (6S)-6-(ETHYL(2-(2-THIENYL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENOL

ABSOLUTE

(6S)-6-(ETHYL(2-(2-THIENYL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENOL

Showing 1 - 10 of 26 results

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