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Search results for clavulanate in Related Substance Name (approximate match)
Showing 1 - 3 of 3 results
Status:
US Approved Rx
(2023)
Source:
ANDA209351
(2023)
Source URL:
First approved in 1984
Source:
AUGMENTIN '250' by US ANTIBIOTICS
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It is a β-lactam
structurally related to the penicillins and possesses the ability to inactivate a wide variety of
β-lactamases by blocking the active sites of these enzymes. Clavulanic acid is particularly active
against the clinically important plasmid-mediated β-lactamases frequently responsible for transferred
drug resistance to penicillins and cephalosporins. Clavulanic acid is used in conjunction with amoxicillin for the treatment of bronchitis and urinary tract, skin, and soft tissue infections caused by beta-lactamase producing organisms. Clavulanic acid competitively and irreversibly inhibits a wide variety of beta-lactamases, commonly found in microorganisms resistant to penicillins and cephalosporins. Binding and irreversibly inhibiting the beta-lactamase results in a restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacteria. By inactivating beta-lactamase (the bacterial resistance protein), the accompanying penicillin/cephalosporin drugs may be made more potent as well.
Status:
Possibly Marketed Outside US
Source:
21 CFR 358
(2010)
Source URL:
First approved in 2010
Source:
21 CFR 358
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)