U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
US Approved OTC
Source:
21 CFR 346.10(i) anorectal:local anesthetic tetracaine hydrochloride
Source URL:
First marketed in 1932

Class (Stereo):
CHEMICAL (ACHIRAL)



Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Tetracaine blocks sodium ion channels required for the initiation and conduction of neuronal impulses thereby affecting local anesthesia. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
mixture
Status:
US Previously Marketed
Source:
21 CFR 310.527(a) hair loss prevention polysorbate 60
Source URL:
First approved in 1938
Source:
Belladonna and Opium by Bryant Ranch Prepack
Source URL:

Class:
MIXTURE

Status:
US Previously Marketed
Source:
21 CFR 310.527(a) hair loss prevention polysorbate 20
Source URL:
First approved in 1978
Source:
60-Second Fluoride Mint by Patterson Dental Supply Inc
Source URL:

Class:
POLYMER

structurally diverse
Status:
US Approved OTC
Source:
21 CFR 349.14(a)(2) ophthalmic:emollient lanolin (in combination)
Source URL:
First marketed in 1921
Source:
Hydrous Wool Fat U.S.P.
Source URL:

Class:
STRUCTURALLY DIVERSE

structurally diverse
Status:
US Previously Marketed
Source:
21 CFR 310.527(a) hair loss prevention wheat germ oil
Source URL:

Class:
STRUCTURALLY DIVERSE

Status:
US Previously Marketed
First marketed in 1936
Source:
sulfanilamide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfanilamide is an anibiotic drug, which has been used for decades for the treatment of vulvovaginal candidiasis. The drug blocks folic acid synthesis in bacterias by inhibitin the enzyme dihydropteroate synthase.