U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Methenamine is an antibacterial agent for preventing recurrent urinary tract infection. It can be used as methenamine hippurate or methenamine mandelate preparations and is United States Food and Drug Administration-approved. Methenamine exerts its activity because it is hydrolyzed to formaldehyde in acid urine.
Status:
US Previously Marketed
Source:
THIOSULFIL SULFAMETHIZOLE by AYER5T
(1961)
Source URL:
First approved in 1953

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfamethizole is an oral antiobiotic, which was used against urinary tract infections under the name Thiosulfil. Sulfamethizole blocks bacterial growth by inhibiting folic acid synthesis via enzyme called dihydropteroate synthase. The drug is no longer marketed in the USA.