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Search results for "brivaracetam" in Code Literal (exact match)
Showing 1 - 1 of 1 results
Status:
US Approved Rx
(2016)
Source:
NDA205836
(2016)
Source URL:
First approved in 2016
Source:
NDA205836
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Brivaracetam (UCB 34714, trade name Briviact), the 4-n-propyl analog of levetiracetam, is a racetam derivative with anticonvulsant properties. Briviact is indicated as adjunctive therapy in the treatment of partial-onset seizures in patients 16 years of age and older with epilepsy. Brivaracetam is believed to act by binding to the ubiquitous synaptic vesicle glycoprotein 2A (SV2A), like levetiracetam, but with 20-fold greater affinity. There is some evidence that racetams including levetiracetam and brivaracetam access the luminal side of recycling synaptic vesicles during vesicular endocytosis. They may reduce excitatory neurotransmitter release and enhance synaptic depression during trains of high-frequency activity, such as is believed to occur during epileptic activity.