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Search results for pirfenidone in WIKIPEDIA (approximate match)
Showing 1 - 1 of 1 results
Status:
US Approved Rx
(2017)
Source:
NDA208780
(2017)
Source URL:
First approved in 2014
Source:
NDA022535
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Pirfenidone is a synthetic antifibrotic agent indicated for the treatment of idiopathic pulmonary fibrosis as Esbriet. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors. It also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. Pirfenidone has demonstrated activity in multiple fibrotic conditions however the exact mechanism of action of pirfenidone in the treatment of IPF has not been established.