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Search results for dicumarol in WHO INTERNATIONAL PHARMACOPEIA (approximate match)
Showing 1 - 1 of 1 results
Status:
US Previously Marketed
Source:
DICUMAROL by ABBVIE
(1944)
Source URL:
First approved in 1944
Source:
DICUMAROL by ABBVIE
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Dicumarol is an coumarin-like compound found in sweet clover. It is used as oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. Dicumarol is also used in biochemical experiments as an inhibitor of reductases.