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Restrict the search for lurasidone to a specific field?

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There is one exact (name or code) match for lurasidone

LURASIDONE

22IC88528T

Search for Structure

Status:

US Approved Rx (2019)

Source:

ANDA208049

(2019)

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=208049

First approved in 2010

Source:

NDA200603

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=200603

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 7

5-hydroxytryptamine receptor 2A

D(2) dopamine receptor

Conditions:

Bipolar depression

Major depressive disorder

Lurasidone is a novel antipsychotic agent approved for the treatment of schizophrenia in a number of countries including the UK and is also approved in the USA and Canada for the treatment of bipolar depression as either a monotherapy or adjunctive therapy with lithium or valproate. In addition, lurasidone is in phase III of a clinical trial for the treatment patient with major depressive disorder and for the treatment of irritability associated with autistic disorder. The mechanism of action of lurasidone, as with other drugs having efficacy in schizophrenia, is unknown but is known, that lurasidone has a high affinity for dopamine D2, serotonin 5-HT2A and serotonin 5-HT7 receptors where it has antagonist effects. In addition, lurasidone is a partial agonist at the serotonin 5-HT1A receptor and has no appreciable affinity for histamine or muscarinic receptors.

Showing 1 - 10 of 24 results

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LURASIDONE

22IC88528T

Search for Structure

Status:

US Approved Rx (2019)

Source:

ANDA208049

(2019)

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=208049

First approved in 2010

Source:

NDA200603

Source URL:

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=200603

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 7

5-hydroxytryptamine receptor 2A

D(2) dopamine receptor

Conditions:

Bipolar depression

Major depressive disorder

Lurasidone is a novel antipsychotic agent approved for the treatment of schizophrenia in a number of countries including the UK and is also approved in the USA and Canada for the treatment of bipolar depression as either a monotherapy or adjunctive therapy with lithium or valproate. In addition, lurasidone is in phase III of a clinical trial for the treatment patient with major depressive disorder and for the treatment of irritability associated with autistic disorder. The mechanism of action of lurasidone, as with other drugs having efficacy in schizophrenia, is unknown but is known, that lurasidone has a high affinity for dopamine D2, serotonin 5-HT2A and serotonin 5-HT7 receptors where it has antagonist effects. In addition, lurasidone is a partial agonist at the serotonin 5-HT1A receptor and has no appreciable affinity for histamine or muscarinic receptors.

ENT-LURASIDONE

LLK3D758RH

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

(2S,3S,4S,5R)-3,4,5-TRIHYDROXY-6-(((1R,2R)-2-(((3AR,4R,7S,7AS)-8-HYDROXY-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBONYL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID

RT9G375JW3

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE, HEXAHYDRO-8-HYDROXY-2-(((1R,2R)-2-((4-(IMINO(2-(METHYLTHIO)PHENYL)METHYL)-1-PIPERAZINYL)METHYL)CYCLOHEXYL)METHYL)-, STEREOISOMER

GS4J4W9MA0

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

(1R,2R)-2-(((3AR,4R,7S,7AS,8S)-8-HYDROXY-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBOXYLIC ACID

6UZ3937LJP

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

ID-20222

BI217QK2ET

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE, HEXAHYDRO-2-(((1R,2R)-2-((4-(1-OXIDO-1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL)METHYL)CYCLOHEXYL)METHYL)-, (3AR,4S,7R,7AS)-

QX95ZN7H2D

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

(2S,3S,4S,5R,6S)-6-(((1R,2R)-2-(((3AR,4S,7R,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBONYL)OXY)-3,4,5-TRIHYDROXYTETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID

UKE5P56E4F

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

ID-14326

5Z4T08JI5F

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

ID-14283

QTG3YT8MBY

Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Structure of LURASIDONE

ABSOLUTE

Structure of ENT-LURASIDONE

ABSOLUTE

Structure of (2S,3S,4S,5R)-3,4,5-TRIHYDROXY-6-(((1R,2R)-2-(((3AR,4R,7S,7AS)-8-HYDROXY-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBONYL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID

ABSOLUTE

(2S,3S,4S,5R)-3,4,5-TRIHYDROXY-6-(((1R,2R)-2-(((3AR,4R,7S,7AS)-8-HYDROXY-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBONYL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID

Structure of 4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE, HEXAHYDRO-8-HYDROXY-2-(((1R,2R)-2-((4-(IMINO(2-(METHYLTHIO)PHENYL)METHYL)-1-PIPERAZINYL)METHYL)CYCLOHEXYL)METHYL)-, STEREOISOMER

ABSOLUTE

4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE, HEXAHYDRO-8-HYDROXY-2-(((1R,2R)-2-((4-(IMINO(2-(METHYLTHIO)PHENYL)METHYL)-1-PIPERAZINYL)METHYL)CYCLOHEXYL)METHYL)-, STEREOISOMER

Structure of (1R,2R)-2-(((3AR,4R,7S,7AS,8S)-8-HYDROXY-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBOXYLIC ACID

ABSOLUTE

(1R,2R)-2-(((3AR,4R,7S,7AS,8S)-8-HYDROXY-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBOXYLIC ACID

Structure of ID-20222

ABSOLUTE

Structure of 4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE, HEXAHYDRO-2-(((1R,2R)-2-((4-(1-OXIDO-1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL)METHYL)CYCLOHEXYL)METHYL)-, (3AR,4S,7R,7AS)-

ABSOLUTE

4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE, HEXAHYDRO-2-(((1R,2R)-2-((4-(1-OXIDO-1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL)METHYL)CYCLOHEXYL)METHYL)-, (3AR,4S,7R,7AS)-

Structure of (2S,3S,4S,5R,6S)-6-(((1R,2R)-2-(((3AR,4S,7R,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBONYL)OXY)-3,4,5-TRIHYDROXYTETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID

ABSOLUTE

(2S,3S,4S,5R,6S)-6-(((1R,2R)-2-(((3AR,4S,7R,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL)METHYL)CYCLOHEXANE-1-CARBONYL)OXY)-3,4,5-TRIHYDROXYTETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID

Structure of ID-14326

ABSOLUTE

Structure of ID-14283

ABSOLUTE

Showing 1 - 10 of 24 results

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