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Restrict the search for
equilin
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There is one exact (name or code) match for equilin
Status:
Investigational
Source:
J Reprod Med. Dec 1999;44(12):1012-20.: Not Applicable Human clinical trial Completed N/A
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Equilin is one of the active components of estrogens used in estrogen replacement therapy. This compound is used as a sulfate conjugate in drug Premarin. Equili is an inhibitor of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), a key enzyme responsible for elevated levels of 17beta-estradiol (E2) in breast tumor tissues. Thus equilin reduce the E2 levels in breast tissues and hence the reduce risk of estrogen-dependent breast cancer.
Showing 1 - 7 of 7 results
Status:
Investigational
Source:
J Reprod Med. Dec 1999;44(12):1012-20.: Not Applicable Human clinical trial Completed N/A
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Equilin is one of the active components of estrogens used in estrogen replacement therapy. This compound is used as a sulfate conjugate in drug Premarin. Equili is an inhibitor of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), a key enzyme responsible for elevated levels of 17beta-estradiol (E2) in breast tumor tissues. Thus equilin reduce the E2 levels in breast tissues and hence the reduce risk of estrogen-dependent breast cancer.
Status:
Possibly Marketed Outside US
Source:
PREMARIN
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Equilin sulfate is one of the main component, which is responsible for the pharmacological action of the PREMARIN, conjugated estrogens tablets. Premarin is used to treat the moderate to severe vasomotor symptoms, vulvar and vaginal atrophy due to menopause. It is also used to treat hypoestrogenism due to hypogonadism, castration or primary ovarian failure; to treat breast cancer and advanced androgen-dependent carcinoma of the prostate (for Palliation Only). In addition, premarin is used to prevent postmenopausal osteoporosis. Equilin sulfate is a prodrug, which is hydrolyzed to the corresponding free estrogen equilin, an inhibitor of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). Human 17beta-HSD1 catalyzes the reduction of inactive estrone (E1) to the active 17beta-estradiol in breast tissues, is a key enzyme responsible for elevated levels of E2 in breast tumor tissues. Thus equilin reduce the E2 levels in breast tissues and hence the reduce risk of estrogen-dependent breast cancer.
Status:
US Approved Rx
(1977)
Source:
ANDA084951
(1977)
Source URL:
First approved in 1966
Source:
MENRIUM 5-2 by ROCHE
Source URL:
Class:
MIXTURE
Status:
US Approved Rx
(2003)
Source:
NDA021417
(2003)
Source URL:
First approved in 1942
Source:
NDA004782
Source URL:
Class:
MIXTURE
Status:
US Previously Marketed
Source:
ENJUVIA by DURAMED
(2004)
Source URL:
First approved in 2004
Source:
ENJUVIA by DURAMED
Source URL:
Class:
MIXTURE
Status:
US Previously Marketed
Source:
CENESTIN by ASPEN
(1999)
Source URL:
First approved in 1999
Source:
CENESTIN by ASPEN
Source URL:
Class:
MIXTURE
Status:
Possibly Marketed Outside US
Source:
PREMARIN
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Equilin sulfate is one of the main component, which is responsible for the pharmacological action of the PREMARIN, conjugated estrogens tablets. Premarin is used to treat the moderate to severe vasomotor symptoms, vulvar and vaginal atrophy due to menopause. It is also used to treat hypoestrogenism due to hypogonadism, castration or primary ovarian failure; to treat breast cancer and advanced androgen-dependent carcinoma of the prostate (for Palliation Only). In addition, premarin is used to prevent postmenopausal osteoporosis. Equilin sulfate is a prodrug, which is hydrolyzed to the corresponding free estrogen equilin, an inhibitor of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). Human 17beta-HSD1 catalyzes the reduction of inactive estrone (E1) to the active 17beta-estradiol in breast tissues, is a key enzyme responsible for elevated levels of E2 in breast tumor tissues. Thus equilin reduce the E2 levels in breast tissues and hence the reduce risk of estrogen-dependent breast cancer.
