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US Approved Rx

2

Possibly Marketed Outside US

1

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Primary Target

Antithrombin-III

1

Fibroblast growth factor receptor

1

Leukocyte adhesion molecule-1

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P-selectin

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Highest Phase

Approved

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Approval Year

1939

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1996

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Unknown

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Condition

Interstitial cystitis

1

peripheral arterial embolism

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pulmonary embolism

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venous thrombosis

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Treatment Modality

Palliative

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Primary

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CNS Penetrant

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Polymer

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CAS

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DRUG BANK

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EVMPD

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FDA UNII

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NCI_THESAURUS

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ATC Level 1

CARDIOVASCULAR SYSTEM

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BLOOD AND BLOOD FORMING ORGANS

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GENITO URINARY SYSTEM AND SEX HORMONES

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ATC Level 2

VASOPROTECTIVES

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ANTITHROMBOTIC AGENTS

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OPHTHALMOLOGICALS

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UROLOGICALS

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ATC Level 3

ANTIVARICOSE THERAPY

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ANTITHROMBOTIC AGENTS

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OTHER OPHTHALMOLOGICALS

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UROLOGICALS

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ATC Level 4

Heparins or heparinoids for topical use

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Heparin group

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Other ophthalmologicals

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Search results for "VATC|VASOPROTECTIVES|ANTIVARICOSE THERAPY|Heparins or heparinoids for topical use" in comments (approximate match)

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HEPARIN

T2410KM04A

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Status:

US Approved Rx (2020)

First approved in 1939

Class:

POLYMER

Targets:

Antithrombin-III

Leukocyte adhesion molecule-1

Conditions:

venous thrombosis

peripheral arterial embolism

pulmonary embolism

Нeparin (or Unfractionated heparin ) is an anticoagulant indicated for both the prevention and treatment of thrombotic events such as deep vein thrombosis (DVT) and pulmonary embolism (PE) as well as atrial fibrillation (AF). Heparin can also be used...

to prevent excess coagulation during procedures such as cardiac surgery, extracorporeal circulation or dialysis, including continuous renal replacement therapy. Heparin administration can be by intravenous (or subcutaneous route. Intravenous heparin is continuously administered for therapeutic anticoagulation, while intermittent subcutaneous administration is used to prevent thromboembolism. Once administered, heparin binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. The heparin-ATIII complex can also inactivate factors IX, XI, XII, and plasmin, but the antithrombotic effect of heparin is well correlated to the inhibition of factor Xa. Typical adverse effects from heparin use include bleeding, thrombocytopenia, injection site reactions, and other adverse effects only seen with chronic heparin administration. Bleeding is a major complication associated with heparin use. Patients should undergo monitoring for new bleeding that may present in the urine or stool. Bleeding may also present as bruising, petechial rash and nosebleeds.

PENTOSAN POLYSULFATE SODIUM

914032762Y

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Status:

US Approved Rx (1996)

First approved in 1996

Class:

POLYMER

Targets:

Fibroblast growth factor receptor

Conditions:

Interstitial cystitis

Pentosan polysulfate sodium (brand name ELMIRON) is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects and is indicated for the relief of bladder pain or discomfort associated with interstitial cystitis. The m...

echanism of action of pentosan polysulfate sodium in interstitial cystitis is not known but was discovered, that it t binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors.

LYAPOLATE SODIUM

9461405D9F

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Status:

Possibly Marketed Outside US

Class:

POLYMER

HHS VULNERABILITY DISCLOSURE

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