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Showing 1 - 10 of 63 results

Status:
US Approved Rx (2011)
First approved in 2003

Class (Stereo):
CHEMICAL (RACEMIC)



Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer. Epinastine is a topically active, direct H1-receptor antagonist and an inhibitor of the release of histamine from the mast ce...
Status:
US Approved Rx (2002)
First approved in 2001

Class (Stereo):
CHEMICAL (ACHIRAL)



Desloratadine is an active, descarboethoxy metabolite of loratadine. It acts by selective inhibition of H1 histamine receptor and thus provides relief to patients with allergic rhinitis and chronic idiopathic urticaria. Desloratadine was approved by ...
Status:
US Approved Rx (2006)
First approved in 1999

Class (Stereo):
CHEMICAL (ACHIRAL)



Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis. Ketotifen was developed in 1970 by Sandoz Pharmac...
Status:
US Approved Rx (1997)
First approved in 1996

Class (Stereo):
CHEMICAL (RACEMIC)



Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the...
Status:
US Approved Rx (2012)
First approved in 1996

Class (Stereo):
CHEMICAL (RACEMIC)



Azelastine, a phthalazine derivative, is an antihistamine and mast cell stabilizer. Azelastine is oxidatively metabolized to the principal active metabolite, desmethylazelastine, by the cytochrome P450 enzyme system. It is indicated for the relief of...
Status:
US Approved Rx (2011)
First approved in 1995

Class (Stereo):
CHEMICAL (ABSOLUTE)



Levocetirizine dihydrochloride is the R enantiomer of cetirizine hydrochloride, a racemic compound with antihistaminic properties. Levocetirizine is a third-generation non-sedative antihistamine indicated for the relief of symptoms associated with se...
Status:
US Approved Rx (2018)
First approved in 1993

Class (Stereo):
CHEMICAL (ACHIRAL)



Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system...
Status:
US Approved Rx (2008)
First approved in 1988

Class (Stereo):
CHEMICAL (RACEMIC)



Cetirizine, a human metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H1 receptors. It is indicated for the relief of nasal and non-nasal symptoms associated with seasonal or per...
Status:
US Approved Rx (1997)
First approved in 1977

Class (Stereo):
CHEMICAL (ABSOLUTE)



Clemastine is an antihistamine with anticholinergic (drying) and sedative side effects. Clemastine is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads...
Status:
US Approved Rx (2006)
First approved in 1951

Class (Stereo):
CHEMICAL (RACEMIC)



Promethazine is a phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. Promethazine HCl Oral Solution is useful for: perennial and seasonal allergic rhinitis. Allergic conjunctivitis due to inhalant allergens ...