{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
Search results for "Pharmacologic Substance[C1909]|Enzyme Inhibitor[C471]|Telomerase Inhibitor" in comments (approximate match)
Showing 1 - 3 of 3 results
Status:
US Approved Rx
(2024)
Source:
NDA217779
(2024)
Source URL:
First approved in 2024
Source:
NDA217779
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Status:
US Approved Rx
(2024)
Source:
NDA217779
(2024)
Source URL:
First approved in 2024
Source:
NDA217779
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Status:
Designated
Source:
FDA ORPHAN DRUG:823621
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Sodium arsenite is an inoganic sodium salt with formula with formula NaAsO2. It has a role as an insecticide, an antibacterial agent, a herbicide, a rodenticide, a carcinogenic agent, an antineoplastic agent and an antifungal agent. It is an arsenic molecular entity and an inorganic sodium salt. Sodium arsenite demonstrated in vitro scolicidal effect against E. granulosus protoscoleces. Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. Sodium arsenite is an effective drug for the treatment of acute promyelocytic leukemia with little nonspecific toxicity. Sodium metaarsenite (KML-001) displaces hTERT from the nucleus and is synergistic with cisplatin. It was used in the clinical trials for the treatment of advanced solid tumors.