Search results for "ORPHAN DRUG|Designated|Treatment of T-cell lymphoma" in comments (approximate match)
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Duvelisib (IPI-145), is an orally available, small-molecule, selective dual inhibitor of phosphatidylinositol 3 kinase (PI3K) δ and γ isoforms originated by Intellikine (owned by Takeda) and developed by Infinity Pharmaceuticals. Orally administered ...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Tipifarnib is an oral farnesyltransferase (FTase) inhibitor which was developed by Janssen (J&J). Upon administration, tipifarnib inhibits FTase and thus suppresses the activity of downstream effectors. The drug reached phase III of clinical tria...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
GGTI-2418, also known as PTX100, is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. In preclinical studies, GGTI-...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Hypericin (4,5,7,4',5',7'-hexahydroxy-2,2'-dimethylnaphtodianthrone) is a naturally occurring chromophore found in some species of the genus Hypericum, especially Hypericum perforatum L. (St. John's wort), and in some basidiomycetes (Dermocybe spp.) ...
