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Cytochrome P450 1A2

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Phopholipase A2

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1997

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Thrombocythemia

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Bristol-Myers Squibb

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Search results for "ORPHAN DRUG|Designated|Treatment of Gastrointestinal Stromal Tumors" in comments (approximate match)

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ANAGRELIDE

K9X45X0051

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Status:

US Approved Rx (2017)

First approved in 1997

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Cytochrome P450 1A2

Phopholipase A2

Phosphodiesterase 3

Conditions:

Thrombocythemia

Anagrelide is an orally active quinazinolone derivative that was originally developed as an antiplatelet drug. The drug inhibits cyclic nucleotide phosphodiesterase III (PDEIII) and phopholipase A2, which is thought to cause the side effects of vasod...

ilation, positive inotropism, reduced platelet aggregation. However, significant inhibition of platelet aggregation is observed only at doses of anagrelide higher than those required to reduce platelet count. It is indicated for the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders. Commonly reported side effects of anagrelide include: abdominal pain, dizziness, headache, nausea, and palpitations. Other side effects include: back pain, fever, tachycardia, vomiting, and anorexia. There is a single case report, which suggests that sucralfate may interfere with anagrelide absorption. Anagrelide is an inhibitor of cyclic AMP PDE III. The effects of medicinal products with similar properties such as inotropes milrinone, enoximone, amrinone, olprinone and cilostazol may be exacerbated by anagrelide.

Bezuclastinib

2ROQ545LAG

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

IDRX-42

Y6UHU32G5Z

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Status:

Designated

Class (Stereo):

CHEMICAL (ACHIRAL)

ILIXADENCEL

PY29292DVJ

Status:

Investigational

Class:

STRUCTURALLY DIVERSE

HHS VULNERABILITY DISCLOSURE

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