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US Approved Rx

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Sphingosine 1-phosphate receptor Edg-1

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Sphingosine 1-phosphate receptor Edg-3

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Sphingosine 1-phosphate receptor Edg-6

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Multiple sclerosis

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Mitsubishi Pharma

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Search results for "LiverTox|Immunomodulatory|Multiple sclerosis" in comments (approximate match)

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FINGOLIMOD

3QN8BYN5QF

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Status:

US Approved Rx (2021)

First approved in 2010

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sphingosine 1-phosphate receptor Edg-8

Sphingosine 1-phosphate receptor Edg-6

Sphingosine 1-phosphate receptor Edg-3

Sphingosine 1-phosphate receptor Edg-1

Conditions:

Multiple sclerosis

Fingolimod (FTY720) is a sphingosine 1-phosphate receptor modulator indicated and approved for the treatment of relapsing-remitting multiple sclerosis. Fingolimod (trade name Gilenya, Novartis) is metabolized by sphingosine kinase to the active meta...

bolite, fingolimod-phosphate. Fingolimod-phosphate is a sphingosine 1-phosphate receptor modulator, and binds with high affinity to sphingosine 1-phosphate receptors 1, 3, 4, and 5. Fingolimod-phosphate blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. The mechanism by which fingolimod exerts therapeutic effects in multiple sclerosis is unknown, but may involve reduction of lymphocyte migration into the central nervous system. Fingolimod was approved as a first-in-class, orally active drug for relapsing multiple sclerosis in 2010, and its applications in other disease conditions are currently under clinical trials.

NATALIZUMAB

3JB47N2Q2P

Subunit 1 (450) Similarity Search Subunit 2 (450) Similarity Search Subunit 3 (213) Similarity Search Subunit 4 (213) Similarity Search

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Subunit 1 (450) Similarity Search Subunit 2 (450) Similarity Search Subunit 3 (213) Similarity Search Subunit 4 (213) Similarity Search

Status:

US Approved Rx (2004)

First approved in 2004

Class:

PROTEIN

INTERFERON BETA

V9GU1EM8SF

Subunit 1 (166) Similarity Search

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Subunit 1 (166) Similarity Search

Status:

Possibly Marketed Outside US

Class:

PROTEIN

GLATIRAMER

U782C039QP

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Status:

US Approved Rx (2017)

First approved in 1996

Class:

POLYMER

HHS VULNERABILITY DISCLOSURE

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