Inxight Drugs

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Development Status

Possibly Marketed Outside US

10

US Previously Marketed

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Other

3

Investigational

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Designated

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Primary Target

Branched-chain α-ketoacid dehydrogenase complex

1

Gamma-secretase

1

NIK/NF-kappaB signaling

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Oxidative Stress

1

PI3K/Akt signaling pathway

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1921

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2023

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1951

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1955

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Alzheimer’s disease

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Breast cancer

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Type 2 diabetes mellitus

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Vitamin deficiency

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CNS Active

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Dozois, K.P. et al.

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Lohmann, K.|Schuster, P.H.

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DSLD

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ENZYME

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ATC Level 1

DERMATOLOGICALS

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BLOOD AND BLOOD FORMING ORGANS

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ATC Level 2

OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM

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OTHER HEMATOLOGICAL AGENTS

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PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS

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ENZYMES

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OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM

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Enzymes

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Proteolytic enzymes

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Search results for "Dietary Supplement Label Database|Enzyme" in comments (approximate match)

Showing 1 - 10 of 21 results

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PINITOL

TF9HZN9T0M

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Status:

Possibly Marketed Outside US

First approved in 2013

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

NIK/NF-kappaB signaling

PI3K/Akt signaling pathway

Oxidative Stress

Gamma-secretase

Conditions:

Alzheimer’s disease

Type 2 diabetes mellitus

Methylinositol is a natural product in the family of inositols. It is found in many foods as well as pine tree bark. Methylinositol is found naturally in many foods and is commercially available as an approved food supplement. Methylinositol can medi...

ate insulin action to improve glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus, especially in patients with insulin resistance. It plays a positive role in regulating insulin-mediated glucose uptake in the liver through translocation and activation of the PI3K/Akt signaling pathway. The compound also modulates gamma-secretase to reduce A-betta production while sparing cleavage of the gamma-secretase substrate Notch. Methylinositol improves cognitive function and memory deficits in preclinical models of Alzheimer's disease (AD) neuropathology. Methylinositol was will tolerated in the population of AD subjects of varying age and severity. No serious adverse effects were detected in clinical trials. Many plant-derived compounds have excellent therapeutic potential against various human ailments. It was shown, that methylinositol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-κB.

COCARBOXYLASE

Q57971654Y

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Status:

Possibly Marketed Outside US

First approved in 2011

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Branched-chain α-ketoacid dehydrogenase complex

Conditions:

Vitamin deficiency

Vitamin deficiency

Cocarboxylase is the coenzyme form of Vitamin B1 present in many animal tissues. Thiamine pyrophosphate (cocarboxylase) is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. Pan...

creatic cells obtain thiamin from their surroundings and enzymatically convert it into thiamin pyrophosphate (TPP) in the cytoplasm; TPP is then taken up by mitochondria via a specific carrier the mitochondrial TPP transporter (MTPPT; product of the SLC25A19 gene).

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM

9X7O8V25IT

Status:

US Approved Rx (2020)

First approved in 1965

Class:

MIXTURE

PHYTASE (ASPERGILLUS NIGER)

2I5T75YG19

Status:

Investigational

Class:

MIXTURE

BROMELAINS

U182GP2CF3

Status:

US Previously Marketed

First approved in 1962

Class:

MIXTURE

TRYPSIN, UNSPECIFIED FORM

GV54A213NN

Status:

US Previously Marketed

First approved in 1951

Class:

MIXTURE

SUPEROXIDE DISMUTASE (SACCHAROMYCES CEREVISIAE)

W2T4YRA9AD

Status:

Possibly Marketed Outside US

First approved in 1993

Class:

MIXTURE

ANANAIN

K0H66D72UT

Subunit 1 (223) Similarity Search

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Subunit 1 (223) Similarity Search

Status:

Designated

Class:

PROTEIN

Chymotrypsin

BVS505O332

Subunit 1 (131) Similarity Search Subunit 2 (97) Similarity Search Subunit 3 (13) Similarity Search

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Subunit 1 (131) Similarity Search Subunit 2 (97) Similarity Search Subunit 3 (13) Similarity Search

Status:

US Previously Marketed

First approved in 1955

Class:

PROTEIN

RENNIN

VT6PI051PW

Subunit 1 (323) Similarity Search

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Subunit 1 (323) Similarity Search

Status:

US Previously Marketed

First marketed in 1921

Class:

PROTEIN

Showing 1 - 10 of 21 results

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