b-Isospartaine is a C2 symmetrical diastereoisomer of Sparteine. It has been found in a variety of Lupus species. b-Isospartaine exhibited the potent acute toxic response for mice but less prominent than (-)-Sparteine has (LD50=92.5 mg/kg vs 47.5mg/kg, respectively).

Dihydro-β-erythroidine is a competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit. Dihydro-β-erythroidine have curare-like effects at peripheral nicotinic receptors, which include severe respiratory depression. Thus in vivo behavioral studies using Dihydro-β-erythroidine are limited. Dihydro-β-erythroidine antagonizes behavioral effects of nicotine in vivo. After s.c. administration, Dihydro-β-erythroidine was potent in blocking nicotine's effects except for antinociception. Intrathecal injection of Dihydro-β-erythroidine was effective in blocking the antinociceptive effect of nicotine.