Vintiamol was developed as a new form of vitamin B1. Information about the current use of this agent is not available.

Tropapride is dopamine D2 receptor antagonist, which potential high antipsychotic activity has been clearly shown in biochemical and pharmacological tests.

Dapitant is an antagonist of neurokinin 1 (NK1) receptor, discovered by the French company Rhône-Poulenc Rorer. NK1 receptors are thought to mediate the neurogenic inflammatory effects of substance P. Dapitant demonstrated efficacy as an antimigraine agent in several animal models. However, in a global, double-blind, randomize, placebo-controlled trial in patients with migraine attacks with moderate or severe headache intensity, treatment with dapitant did not lead to an improvement in the intensity of headache, and the development of the drug was discontinued.

Quillifoline is a quinolizine derivative patented by N. V. Koninklijke Pharmaceutische Fabrieken voorheen Brocades-Stheeman & Pharmacia as adrenolytic, sedative, and vasodilator.

FLUDOREX is an antiemetic and anorexic agent.

Tolpronine possesses significant analgesic properties in mice by the subcutaneous, oral and intraperitoneal routes. The compound is most active subcutaneously, having approximately 20 times the activity of metamizolum on a weight for weight basis. In addition to its analgesic activity, tolpronine also possesses local anesthetic properties, being approximately 1.5 times as active as procaine hydrochloride in the guinea pig intracutaneous wheal test. It is, however, at least twice as toxic by the subcutaneous route. It has an anti-acetylcholine action on the isolated guinea-pig ileum. Excessively large amounts constipate normal mice; a weak spasmolytic effect is seen in the isolated guinea-pig ileum and rabbit duodenum. The jejunum of the anesthetized cat shows a spasmogenic effect. Chronic administration to rats and rabbits caused a reduction in the growth rate of rats.

Tropirine is an antihistaminic, respiratory, anticholinergic agent.

Gemazocine is an opioid antagonist. It was first reported in the literature in the 1970’s, and toxicology studies have been performed to characterize its profile.