AM-114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins. AM 114 also exerts anti-cancer activity against cancer cells, which potently inhibits the growth of human colon cancer HCT116 cells with values of IC50 of 1.5 uM and 0.6 uM in MTT and colony formation assays respectively.

Sodium fluoroborate (sodium tetrafluoroborate) is an inorganic compound with the formula NaBF4. It is used in the sand casting of aluminum, electrochemical processes, and as fluorinating agent. It is also used as an additive in chrome, nickel and cadmium plating baths. Sodium tetrafluoroborate may be used as a catalyst for the synthesis of bis(indolyl)methanes via electrophilic substitution reaction of indoles with aldehydes and ketones. It may also be used as a source of tetrafluoroborate anoins during the synthesis of ionic liquids like 1-butyl-3-methylimidazolium tetrafluoroborate[4] and trihexyl(tetradecyl)phosphonium tetrafluoroborate.