U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 651 - 660 of 39585 results

Status:
US Animal Drug
Source:
21 CFR 520.1802a PART 520-ORAL DOSAGE FORM NEW ANIMAL DRUGS piperazine-carbon disulfide complex
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Picadex is a dithiocarbamate derivative of piperazine. It was used in veterinary as an antihelmintic drug. It was shown to be effective in the treatment of Oesophagostamum infection in pigs.
Status:
Investigational
Source:
INN:dalvastatin
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Dalvastatin is a synthetic HMG-CoA reductase inhibitor developed by Rhône-Poulenc Rorer. Dalvastatin is a prodrug and is itself an inactive lactone. After oral ingestion, the drug is hydrolyzed in vivo to the corresponding beta-hydroxy acid, which is the pharmacologically active form. HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway. An active form of dalvastatin inhibits HMG-CoA reductase with IC50 of 3.4 nM. In ex vivo assay, orally administered dalvastatin inhibited cholesterol biosynthesis in rat liver slices with an ED50 value of 0.9. The efficacy of dalvastatin to lower cholesterol was investigated in the clinical trials in the 1990s, but no results were reported.
Status:
Investigational
Source:
INN:gadosircoclamide [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
NCT03020056: Not Applicable Interventional Completed Cataract Surgery
(2017)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:segatroxaban [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:irodanoprost [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:netanasvir [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:moxetomidate [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:fosrolapitant [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT02444910: Phase 2 Interventional Completed Diabetes Mellitus, Type 2
(2015)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)