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Showing 51 - 60 of 4,342 results

Status:
US Approved Rx (2022)
First approved in 2004

Class (Stereo):
CHEMICAL (ABSOLUTE)



Pemetrexed is a new-generation antifolate, approved for the treatment of mesothelioma and non-small cell lung cancer, currently being evaluated for the treatment of a variety of other solid tumors. Pemetrexed, is a folate analog metabolic inhibitor ...
Status:
US Approved Rx (2020)
First approved in 2004

Class (Stereo):
CHEMICAL (ABSOLUTE)



Cinacalcet is a positive allosteric modulator of calcium sensing receptor. The drug is approved by FDA (Sensipar trade name) and used for the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease on dialysis; hyperc...
Status:
US Approved Rx (2017)
First approved in 2003

Class (Stereo):
CHEMICAL (ABSOLUTE)



Daptomycin is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. Daptomycin has a distinct mechanism of action, disrupting multiple aspects of bacterial cell membrane function...
Status:
US Approved Rx (2022)
First approved in 2003

Class (Stereo):
CHEMICAL (ABSOLUTE)



Bortezomib is the therapeutic proteasome inhibitor. First, which is tested in humans. The boron atom in bortezomib binds the catalytic site of the 26S proteasome with high affinity and specificity. Bortezomib is approved in the U.S. for treating rela...
Status:
US Approved Rx (2012)
First approved in 2003

Class (Stereo):
CHEMICAL (ACHIRAL)



Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by th...
Status:
US Approved Rx (2022)
First approved in 2003

Class (Stereo):
CHEMICAL (ACHIRAL)



Gefitinib is an anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme. Thus the function of the EGFR t...
Status:
US Approved Rx (2008)
First approved in 2003

Class (Stereo):
CHEMICAL (ABSOLUTE)



Fosaprepitant (Emend for Injection (US), Ivemend (EU)) is a prodrug of Aprepitant. Once biologically activated, the drug acts as a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for...
Status:
US Approved Rx (2017)
First approved in 2002

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Oxaliplatin (brand name Eloxatin), a new generation of platinum derivatives discovered by Prof Kidani in 1976 at Nagoya University in Japan, was licensed-in and developed by Debiopharm. Eloxatin is typically administered in combination with fluoroura...
Status:
US Approved Rx (2002)
First approved in 2002

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Eletriptan (eletriptan hydrobromide, trade name Relpax) is a selective 5-hydroxytryptamine (5-HT1B/1D) serotonin receptor agonist (triptan) indicated for the acute treatment of migraine with or without aura in adults. Eletriptan binds with high affin...
Status:
US Approved Rx (2011)
First approved in 2001

Class (Stereo):
CHEMICAL (ACHIRAL)



Desloratadine is an active, descarboethoxy metabolite of loratadine. It acts by selective inhibition of H1 histamine receptor and thus provides relief to patients with allergic rhinitis and chronic idiopathic urticaria. Desloratadine was approved by ...