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Restrict the search for
nonoxynol-9
to a specific field?
Status:
Possibly Marketed Outside US
Class:
CONCEPT
Status:
Possibly Marketed Outside US
Source:
NCT03180034: Phase 4 Interventional Active, not recruiting Human Papillomavirus Infection
(2017)
Source URL:
Class:
CONCEPT
Status:
Possibly Marketed Outside US
Source:
NCT03180034: Phase 4 Interventional Active, not recruiting Human Papillomavirus Infection
(2017)
Source URL:
Class:
CONCEPT
Status:
US Approved Rx
(2024)
Source:
NDA218944
(2024)
Source URL:
First approved in 2024
Source:
NDA218944
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
US Approved Rx
(2024)
Source:
NDA218730
(2024)
Source URL:
First approved in 2024
Source:
NDA218730
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
US Approved Rx
(2024)
Source:
NDA218784
(2024)
Source URL:
First approved in 2024
Source:
NDA218784
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Vorasidenib (also known as AG 881) was developed as an isocitrate dehydrogenase (IDH) type 1 in the cytoplasm and type 2 in the mitochondria, with potential antineoplastic activity. It is known that IDH is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Isocitrate dehydrogenases 1 and 2 (IDH1/2) are homodimeric enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) in the tricarboxylic acid cycle. Vorasidenib participated in phase I clinical trials in patients with advanced hematologic malignancies and in gliomas.
Status:
US Approved Rx
(2024)
Source:
NDA218730
(2024)
Source URL:
First approved in 2024
Source:
NDA218730
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
US Approved Rx
(2024)
Source:
NDA217899
(2024)
Source URL:
First approved in 2024
Source:
NDA217899
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
MBX-8025 (Seladelpar) is an agonist of peroxisome proliferator-activated receptor delta. MBX-8025 improves insulin sensitivity and reverses dyslipidemia and hepatic storage of lipotoxic lipids to improve nonalcoholic steatohepatitis pathology in atherogenic diet-fed obese diabetic mice. MBX-8025 improves lipoprotein subfractions associated with atherogenic dyslipidemia. CymaBay Therapeutics is developing MBX-8025 for the treatment of patients with the autoimmune liver disease, primary biliary cholangitis and nonalcoholic steatohepatitis.
Status:
US Approved Rx
(2024)
Source:
NDA217865
(2024)
Source URL:
First approved in 2024
Source:
NDA217865
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Gavinostat is an orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Gavinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. At low, nonapoptotic concentrations, this agent inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-6 and interferon-gamma. It is currently in phase 2 trials for Myeloproliferative disorders, Polycythaemia vera and Phase III for Duchenne muscular dystrophy announced. In clinical trials of givinostat as a salvage therapy for advanced Hodgkin's lymphoma, the most common adverse reactions were fatigue, mild diarrhea or abdominal pain, moderate thrombocytopenia, and mild leukopenia.
Status:
US Approved Rx
(2024)
Source:
NDA217779
(2024)
Source URL:
First approved in 2024
Source:
NDA217779
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
