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aspirin
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
8-Iso-prostaglandin E2 (8-iso-PGE2) is one of the several isoprostanes produced from arachidonic acid during lipid peroxidation. Isoprostanes are a group of stable prostaglandin-like compounds produced by free radical-catalyzed, non-enzymatic peroxidation of arachidonic acid, which are used as markers of oxidative stress in several human diseases, including diabetes. In addition, 8-iso-prostaglandin E2 is biologically active compound involved in contraction of vascular smooth muscle and activation of platelets. 8-iso-PGE2 has been demonstrated to be the most potent vasoconstrictor isoprostane on the human umbilical artery and vein, activating the TPα isoform, which is present in the human umbilical vein and platelets. 8-iso-prostaglandin E2 stimulates human umbilical vein endothelial cells to specifically bind monocytes and this effect is mediated by cyclic AMP/protein kinase A- and p38 MAP kinase-dependent pathways and is independent of the classical inflammatory NFkappaB pathway.
