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Search results for nonoxynol root_references_@count in root_references_@count (approximate match)
Status:
Investigational
Source:
NCT00004828: Phase 1 Interventional Completed Tricuspid Atresia
(1994)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
A radioconjugate of synthetic active thyroid hormone, liothyronine (T3), labeled with Iodine 131. Liothyronine involves many important metabolic functions and is essential to the proper development and differentiation of all cells. I131 liothyronine may be used in radiotherapy in thyroid cancers.
Status:
Investigational
Source:
NCT04464070: Early Phase 1 Interventional Enrolling by invitation Metabolism of Prostaglandin D2
(2020)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
PGD2 (Prostaglandin D2) is a major cellular regulator, has been shown to bind different receptors: D prostanoid receptor (DP) and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). PGD2 reportedly inhibits platelet aggregation, the proliferation of cells, and activation of neutrophils. This compound is also a potent vasodilator that also relaxes smooth muscle but causes contraction of the bronchial airways. PGD2 promotes T cell migration via CRTH2 and aggravates asthma. In contrast, there have been some studies suggesting that PGD2 exerts anti-inflammatory effects via DP, such as inhibiting the migration and activation of neutrophils, basophils, dendritic cells and T cells. Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and was suggested the PGD(2)-GPR44 pathway as a potential target for treatment. Also was revealed, that PGD2 might be a new target for asthma therapy, PGD2 in serum and BALF were lower in the treated group than in the untreated group.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Probarbital is ethylisopropylbarbituric acid patented by Thorp, L as hypnotic and sedative agent.
Status:
Investigational
Source:
NCT04106557: Phase 3 Interventional Completed Primary Disease or Condition Being Studied: Angelman Syndrome (AS)
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Gaboxadol (or THIP) is a direct GABA mimetic ligand at delta-containing receptors. Gaboxadol went into human clinical trials to test if the drug promoted sleep. It was generally well tolerated. Gaboxadol enhances delta power in NREM sleep in humans. Gaboxadol failed in Phase III for sleep studies. The side effects of Gaboxadol have been described as mild and similar in quality to those of other GABA-mimetics. Gaboxadol is in development with Ovid Therapeutics as a treatment for Angelman syndrome, fragile X syndrome and epilepsy.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Metalkonium is an antiseptic and disinfectant.
Status:
Excipient
Source:
0.12mg ORAL TABLET
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Guinea green B is an organosulfur stain. It is used as a dye for silk and wool fabrics and as a biological stain.
Status:
Designated
Source:
FDA ORPHAN DRUG:833721
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Designated
Source:
FDA ORPHAN DRUG:796620
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Designated
Source:
FDA ORPHAN DRUG:880622
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Designated
Source:
FDA ORPHAN DRUG:926722
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)