{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
Restrict the search for
methyl salicylate
to a specific field?
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2014)
Source URL:
First approved in 2014
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
First approved in 2014
Source:
NADA141427
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Clodronate (also known as clodronic acid) is a drug used to treat a high level of calcium in the blood caused by changes in the body that happen with cancer. Clodronate is approved in some countries and is sold under trade trade name bonefos for oral use. Bonefos is indicated in the management of osteolytic lesions, hypercalcemia and bone pain associated with skeletal metastases in patients with carcinoma of the breast or multiple myeloma. Bonefos is also indicated for the maintenance of clinically acceptable serum calcium levels in patients with hypercalcemia of malignancy initially treated with an intravenous bisphosphonate. Bonefos forms complexes with divalent metal ions, and therefore simultaneous administration with food, antacids and mineral supplements may impair absorption. It was suggested, that the mechanism of action of clodronate was involved osteoclast apoptosis.
Status:
Possibly Marketed Outside US
Source:
NCT02976246: Phase 4 Interventional Completed Vitamin K Supplementation
(2016)
Source URL:
First approved in 2013
Source:
FOSTEUM PLUS by Primus Pharmaceuticals, Inc.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Vitamin K is a fat-soluble vitamin, which exists in two different forms in nature: vitamin K1 (phylloquinone or phytonadione) and vitamin K2 (menaquinones), a feature of which is a long polyprenyl lateral chain. Menaquinone-7 (MK-7) is a form of vitamin K2 that occurs naturally in some animal-derived and is available as an ingredient of dietary supplements. A novel method of marking five different cis/trans isomers of vitamin K2 (MK-7) (including 6-CIS form) in dietary supplements recently was developed and validated.
Status:
Possibly Marketed Outside US
Source:
NCT02976246: Phase 4 Interventional Completed Vitamin K Supplementation
(2016)
Source URL:
First approved in 2013
Source:
FOSTEUM PLUS by Primus Pharmaceuticals, Inc.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Vitamin K is a fat-soluble vitamin, which exists in two different forms in nature: vitamin K1 (phylloquinone or phytonadione) and vitamin K2 (menaquinones), a feature of which is a long polyprenyl lateral chain. Menaquinone-7 (MK-7) is a form of vitamin K2 that occurs naturally in some animal-derived and is available as an ingredient of dietary supplements. A novel method of marking five different cis/trans isomers of vitamin K2 (MK-7) (including 6-CIS form) in dietary supplements recently was developed and validated.
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2013)
Source URL:
First approved in 2013
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Methylinositol is a natural product in the family of inositols. It is found in many foods as well as pine tree bark. Methylinositol is found naturally in many foods and is commercially available as an approved food supplement. Methylinositol can mediate insulin action to improve glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus, especially in patients with insulin resistance. It plays a positive role in regulating insulin-mediated glucose uptake in the liver through translocation and activation of the PI3K/Akt signaling pathway. The compound also modulates gamma-secretase to reduce A-betta production while sparing cleavage of the gamma-secretase substrate Notch. Methylinositol improves cognitive function and memory deficits in preclinical models of Alzheimer's disease (AD) neuropathology. Methylinositol was will tolerated in the population of AD subjects of varying age and severity. No serious adverse effects were detected in clinical trials. Many plant-derived compounds have excellent therapeutic potential against various human ailments. It was shown, that methylinositol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-κB.
Status:
Possibly Marketed Outside US
Source:
21 CFR 333A
(2013)
Source URL:
First approved in 2013
Source:
21 CFR 333A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
21 CFR 333D
(2013)
Source URL:
First approved in 2013
Source:
21 CFR 333D
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Possibly Marketed Outside US
First approved in 2013
Source:
Gilchrist and Soames Moisturizing Lip Balm by ASP Global, LLc
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Brilliant Blue is an organic compound classified as a blue triarylmethane dye. It is coal tar derivative food dye; used as the di-NH4 or di-Na salts. Coloring agent. Brilliant Blue FCF, has been used in foods in the US since 1929. This color adds a distinctive, bright blue hue to beverages, beverage powders, dairy products, baked goods, dessert powders, confections, condiments, icings, syrups, jams, jellies, marmalades, liqueurs, extracts, dairy fats and oil, meat, seafood, snacks, dry mixes and seasonings, fruit preparations, convenient food, and flavors. Both the diammonium and disodium salts of FD&C Blue No. 1 are used. The disodium salt is used in foods, while the diammonium salt has limited usage in drugs and cosmetics.
Status:
Possibly Marketed Outside US
First approved in 2013
Source:
Gilchrist and Soames Moisturizing Lip Balm by ASP Global, LLc
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Brilliant Blue is an organic compound classified as a blue triarylmethane dye. It is coal tar derivative food dye; used as the di-NH4 or di-Na salts. Coloring agent. Brilliant Blue FCF, has been used in foods in the US since 1929. This color adds a distinctive, bright blue hue to beverages, beverage powders, dairy products, baked goods, dessert powders, confections, condiments, icings, syrups, jams, jellies, marmalades, liqueurs, extracts, dairy fats and oil, meat, seafood, snacks, dry mixes and seasonings, fruit preparations, convenient food, and flavors. Both the diammonium and disodium salts of FD&C Blue No. 1 are used. The disodium salt is used in foods, while the diammonium salt has limited usage in drugs and cosmetics.
Status:
Possibly Marketed Outside US
Source:
NCT00955955: Phase 4 Interventional Completed Depression
(2009)
Source URL:
First approved in 2012
Source:
vitaMedMD One Rx by vitaMedMD
Source URL:
Class (Stereo):
CHEMICAL (EPIMERIC)
Targets:
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme required for the formation of 5-methyltetrahydrofolate (5-MTHF), a form of folate able to cross the blood-brain barrier and which is necessary as a substrate for the remethylation of homocysteine to methionine by methionine synthase. Patients with severe MTHFR deficiency cannot make 5-MTHF and have extremely low levels in the CSF. Only treatment with oral 5-MTHF given as calcium mefolinate resulted in an increase in CSF 5-MTHF.
