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Restrict the search for
atorvastatin
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
(3S,5R)-atorvastatin is a stereoisomer of atorvastatin. Atorvastatin is a synthetic hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. 3R,5R enantiopure form of atorvastatin (Lipitor, Pfizer; since Nov 2011 generic) is used clinically. It reduces levels of total cholesterol, low-density lipoprotein (LDL)-cholesterol, triglyceride and very low-density lipoprotein (VLDL)-cholesterol and increases high-density lipoprotein (HDL)-cholesterol in patients with a wide variety of dyslipidaemias.
![Structure of (3R,5R)-7-[5-(4-fluorophenyl)-2-oxo-4-phenyl-3-(phenylcarbamoyl)-3-(propan-2-yl)-2,3-dihydro-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid](/img/47220ec6-3ba8-4be7-b2f9-307676ca6d42.svg?size=200&context=mkzmtlncyv)
