U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 251 - 260 of 521 results

Bornyl acetate is the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, which has displayed an anti-inflammatory effect. In addition was shown, that this compound had therapeutic potentials for the osteoarthritis and may be developed as a preventive agent for lung inflammatory diseases. In combination with 5-fluorouracil, bornyl acetate possesses the anticancer activity by inducing apoptosis, DNA fragmentation as well as G2/M cell cycle arrest.
Status:
Possibly Marketed Outside US
Source:
MEDI-PATCH WITH LIDOCAINERX by Two Hip Consulting, LLC
(2012)
Source URL:
First approved in 2012
Source:
MEDI-PATCH WITH LIDOCAINERX by Two Hip Consulting, LLC
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Citronellyl acetate, a monoterpene product of the secondary metabolism of plants is suitable for all kinds of fruity-floral compounds and flavor compositions. Citronellyl acetate is present mainly in Eucalyptus citriodora, which possesses different biological activities, including fungicidal, larvicidal and bactericidal. As a component of volatile oils from Pelargonium graveoleus Citronellyl acetate exhibited marginal antitumor activities. In addition, some studies revealed, that Citronellyl acetate possessed antinociceptive properties on acute pain. This this is achieved by the involvement of PKC, PKA, TRPV1, TRPA1, TRPM8, and ASIC in Citronellyl acetate's antinociceptive mechanism.
Status:
Possibly Marketed Outside US
Source:
AIVLOSIN by Japan
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Tylvalosin tartrate is a third-generation macrolide antibiotic that has antibacterial activity against Gram-positive, some Gram-negative organisms and mycoplasma. Tylvalosin interferes with protein synthesis by reversibly binding to the 50S ribosome subunit. Tylvalosin binds to the donor site and prevents the translocation necessary for keeping the peptide chain growing. Its effect is essentially confined to rapidly dividing organisms. Tylvalosin tartrate is the active ingredient of Aivlosin -- a modern macrolide that has shown its effectiveness in the control of porcine proliferative enteropathy, EP and swine dysentery.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Benzyl acetate is used as a fragrance ingredient and occurs in different plants and fruits, e.g., jasmine, apple, tea, plum, wine grape. It possesses a sweet and pleasant aroma, owing to which, it finds applications in personal hygiene and health care products.
Status:
Possibly Marketed Outside US
Source:
NCT02158182: Phase 4 Interventional Completed Hepatic Encephalopathy
(2014)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. Ornithine is also a precursor of citrulline and arginine. Arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of arginine in tissues throughout the body. As de novo synthesis of arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to arginine).

Showing 251 - 260 of 521 results