U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 241 - 250 of 476 results

3-Nitropropionic Acid (aka beta-Nitropropionic acid) is a mycotoxin and potent mitochondrial inhibitor. It is produced by a number of fungi and found widely in food, in sugar cane, and in Japanese fungally fermented staples such as miso, soy sauce, and katsuobushi. beta-Nitropropionic acid is also present in some traditional Chinese medicines. beta-Nitropropionic Acid can be systematically administered to produce localized striatal neurodegeneration mimicking the pathological features of Huntington's disease.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Flutolanil is a systemic fungicide for use specifically against basidiomycetes. It inhibits the hyphal growth and infection cushion formation. It is effective against silver scurf, daylily rust, snow mold, yellow patch (R cerealis), southern blight (Sclerotium rolfsii), red thread (Laetisaria fuciformis), fairy ring, all strains of brown patch (Rhizoctonia solani) and even Asian soybean rust (Phakopsora pachyrhizi). Flutolanil is used in crops such as artichokes, beetroot, Brussel sprouts, etc. It has season-long efficacy when applied to seed potatoes. It can be applied to foliage, to soil, or paddy water and as a seed treatment. Flutolanil is extremely safe for both crops and operator. Biochemical mode of action of flutolanil seems to be inhibition of a succinate dehydrogenase complex, an important enzyme complex in the respiratory chain of basidiomycetous fungi but not of fungi in other classes.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Emoxypine (ethylmethylhydroxypyridine) succinate (MEXIDOL®) is a 3-hydroxypyridine derivative which is quite similar in structure to Vitamin B6 (pyridoxine). The most important components of the mechanism of action of Mexidol® are its antioxidant and membranotropic effects, the ability to modulate functioning of receptors and membrane-bound enzymes, restore a neurotransmitter balance. Due to its mechanism of action Mexidol® has a wide range of pharmacological effects, realized on at least two levels – neuronal and vascular. It has antihypoxic, anti-ischemic, neuroprotective, nootropic, vegetotrophic, anti-stress, anxiolytic, anticonvulsant, anti-alcohol, cardioprotective, anti-atherogenic, geroprotective and other actions. Under the action of Mexidol®, it is observed an improvement in cerebral circulation and microcirculation. Emoxypine is distributed in Russia but it is widely unknown in other regions.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Showing 241 - 250 of 476 results