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Restrict the search for
dimethyl fumarate
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
CID-2858522 is the potent and selective inhibitor of protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). CID-2858522 inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. CID-2858522 does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).
