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Restrict the search for
penicillin v
to a specific field?
Status:
Designated
Source:
FDA ORPHAN DRUG:566316
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Designated
Source:
FDA ORPHAN DRUG:18787
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Benzylpenilloic acid is a metabolite of benzylpenicillin. It is produced by hydrolysis of when beta-lactam ring of benzylpenicillin. Along with some other metabolites of penicillin, benzylpenilloic acid is responsible for the allergic reaction to beta-lactam antibiotic. It is a component of a minor determinant mixture (MDM) reagent which is used to evaluate sensitivity to penicillin in the clinic.
Status:
Designated
Source:
FDA ORPHAN DRUG:865621
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Designated
Source:
FDA ORPHAN DRUG:452214
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Status:
Designated
Source:
FDA ORPHAN DRUG:133100
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
3,3',5,5'-Tetraiodothyroacetic acid (Tetrac) is a deaminated analog of L-thyroxine (T4) that blocks the proangiogenesis actions of T4 and 3, 5, 3’-triiodo-L-thyronine as well as other growth factors at the cell surface receptor for thyroid hormone on integrin αvβ3. 3,3',5,5'-Tetraiodothyroacetic acid blocks the transcriptional activities directed by L-thyroxine (T4) and 3,5,3’-triiodo-L-thyronine (T3) at αvβ3, but, independently of T4 and T3, 3,3',5,5'-Tetraiodothyroacetic acid modulates transcription of cancer cell genes that are important to cell survival pathways, control of the cell cycle, angiogenesis (VEGFA, FGF), apoptosis, cell export of chemotherapeutic agents, and repair of double-strand DNA breaks. 3,3',5,5'-Tetraiodothyroacetic acid was found to perturb the angiogenesis process stimulated by VEGF (Vascular Endothelial Growth Factor) or FGF (Fibroblast Growth Factor) without influencing the preexisting blood vessels.
![Structure of Ethyl 4-(1-methylethenyl)-2-propyl-1-[[2?-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1?-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate](/img/937c620d-10e3-46e6-a4b9-f0c17a2438de.svg?size=200&context=lhvyzxgonf)
![Structure of Cyclosporin A, 1-[(2S)-2-aminobutanoic acid]-](/img/f08eeba5-a6ac-4ad3-85b2-712bc8638e3c.svg?size=200&context=lhvyzxgonf)