U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 19731 - 19740 of 21518 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Alfuzosin, a quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder outlet resistance, bladder instability and symptoms associated with benign prostatic hyperplasia are reduced. The two enantiomers (S and R) have the same pharmacological activity as the racemate. Ligand binding and functional studies demonstrate that the alpha1-antagonist properties of alfuzosin reside equally in its two enantiomers. Racemic alfuzosin is indicated for the symptomatic treatment of benign prostatic hyperplasia and adjunctive therapy in acute urinary retention.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Alfuzosin, a quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder outlet resistance, bladder instability and symptoms associated with benign prostatic hyperplasia are reduced. The two enantiomers (S and R) have the same pharmacological activity as the racemate. Ligand binding and functional studies demonstrate that the alpha1-antagonist properties of alfuzosin reside equally in its two enantiomers. Racemic alfuzosin is indicated for the symptomatic treatment of benign prostatic hyperplasia and adjunctive therapy in acute urinary retention.
CYCLAZOSIN HYDROCHLORIDE is a quinazoline derivative pharmacologically characterized as putative a1B-adrenoceptor antagonist.

Showing 19731 - 19740 of 21518 results