U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1941 - 1950 of 4709 results

LDC1267 preferentially inhibits TAM tyrosine kinase receptors Tyro3, Axl and Mer at low nanomolarity. LDC1267 conferred therapeutic potential, efficiently enhancing anti-metastatic natural killer (NK) cells activity. In vivo the compound markedly reduced murine mammary cancer and melanoma metastases dependent on NK cells.
Phenanthridinone, an isoquinoline derivative, is a potent poly(ADP-ribose)polymerase 1 inhibitor. It could be considered as a potent immunomodulator, and also as the prototype of a new class of adjuncts in cancer chemotherapy.
Verticine is a steroidal alkaloid compound extracted from the Fritillaria species of medicinal plants. Verticine was not only able to block the Nav1.7 ion channel but also preferably inhibited the Kv1.3 ion channel. It inhibits the production of inflammatory cytokines induced by LPS through blocking MAPKs and NF-κB signaling pathways. Verticine inhibited the hERG peak tail currents in a concentration dependent manner. Verticine exhibits anti-inflammatory, antitussive, antihypertensive and pain suppression properties.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)

Showing 1941 - 1950 of 4709 results