Bis(3,5-dibromosalicyl)fumarate, a compound that reacts with oxyhemoglobin to cross-link the two beta 82 lysine residues and as a result markedly increases the solubility of deoxyhemoglobin S. It was shown that bis(3,5-dibromosalicyl)fumarate effectively inhibited of sickling, that could be used to develop treatments for sickle-cell anemia. Besides this compound possesses anti-inflammatory, analgesic, and antipyretic effects.

Methyl hesperidin is a flavanone-type flavonoid and a methylated derivative of hesperidin. It exhibits better bioactivities and water-solubility than hesperidin. It could improve the permeability and integrity of the capillary lining and usually found in association with vitamin C to enhance its effect.